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:: Volume 20, Issue 5 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(5): 437-447 Back to browse issues page
Study of Association Between Polymorphism Alpha7 Neuronal Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) with the Development of Schizophrenia in Iranian Population
Shadi Haghighat 1, Rasoul Zahmatkesh Roodsari 2, Reza Ranjbar 3
1- Department of Genetics, School of Biological Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
2- Department of Biology, School of Biological Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran , rasoul130@yahoo.com
3- Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract:   (1238 Views)
Background: SCZ (Schizophrenia) is a common psychiatric and mental in which patients share a common genetic vulnerability. The α7 neuronal nicotinic receptor gene (CHRNA7) is located on the chromosome 15q13-q14. There are several single nucleotide polymorphisms (SNPs) in exons, introns and promoter sites inside the CHRNA7 gene. The aim of this research was to investigate the association between polymorphism CHRNA7 and the development of schizophrenia in Iranian population.
Materials and Methods: This case-control study included 100 patients with schizophrenia and 100 healthy volunteers as a control group. Genomic DNA was extracted from blood samples. Genotypes were determined using the PCR-RFLP method. Statistical analysis was performed using the SPSS software version 20.
Results: Frequency of CC, TCand TT genotypes were 18%, 42% and 40% in patients group  and 14%, 45% and 41%, in normal groups respectively. Statistical analysis indicated that in the total sample including male and female, there was no significant association between CHRNA7 gene polymorphism and schizophrenia disease.
Conclusion: The presence of the T allele in CHRNA7 gene at rs904942 cannot be considered as a risk factor for schizophrenia. Therefore, further genetic studies with more SNPs and larger sample sizes with more heterogenicity are required for more conclusive results.
Keywords: Schizophrenia, polymorphism, CHRNA7, PCR-RFLP
Full-Text [PDF 908 kb]   (286 Downloads)    
Type of Study: Original | Subject: Nervous System
Received: 2017/11/13 | Accepted: 2017/11/13 | Published: 2017/11/13
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Haghighat S, Zahmatkesh Roodsari R, Ranjbar R. Study of Association Between Polymorphism Alpha7 Neuronal Nicotinic Acetylcholine Receptor Subunit Gene (CHRNA7) with the Development of Schizophrenia in Iranian Population. Iran South Med J. 2017; 20 (5) :437-447
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Volume 20, Issue 5 (Iranian South Medical Journal 2017) Back to browse issues page
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