Volume 21, Issue 5 (Iranian South Medical Journal 2018)
Iran South Med J 2018, 21(5): 353-361 |
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Elyaspour Z, Akbarzadeh S, Iranpour D, Bargahei A, Motemed N, Hajian N, et al . Relationship of Serum Levels of Vitamin K2 and Osteocalcin with Atherosclerotic Coronary Arteries. Iran South Med J 2018; 21 (5) :353-361
URL: http://ismj.bpums.ac.ir/article-1-955-en.html
URL: http://ismj.bpums.ac.ir/article-1-955-en.html
Zahra Elyaspour1 
, Samad Akbarzadeh2 , Darush Iranpour3 , Afshar Bargahei1 , Nilofar Motemed4 , Najmeh Hajian1 , Khadejeh Ghasemi3 , Ali Movahed * 5
, Samad Akbarzadeh2 , Darush Iranpour3 , Afshar Bargahei1 , Nilofar Motemed4 , Najmeh Hajian1 , Khadejeh Ghasemi3 , Ali Movahed * 5
1- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- Department of Cardiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Community Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran ,amovahed58@gmail.com
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- Department of Cardiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Community Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran ,
Abstract: (4305 Views)
Background: This study aimed to evaluate the relationship of serum levels of vitamin K2 and osteocalcin with coronary artery plaques in people undergoing angiography.
Materials and Methods: This case-control study enrolled 138 people presenting to Bushehr Heart Center for routine examination. Demographic information of the participants was registered in a standard questionnaire. Before undergoing angiography, 10 ml blood was collected from all the participants and stored at – 80 ˚C until the analysis. After the angiography, those who were found to be normal entered the control group, and those with one or more arteries blocked were placed in the case group. Finally, serum levels of vitamin K2 and osteocalcin were measured in all the samples using ELISA kits.
Results: Serum levels of osteocalcin in the case group were significantly higher than those of the control (P=0.019). There was no difference in K2 levels between the two groups (P=0.84). Moreover, no relationship was found between the osteocalcin levels and the number of blocked arteries and the severity of atherosclerosis (P=0.95). By adjusting age and type 2 diabetes in both groups, a difference was observed in the concentration of osteaocalcin and coronary artery atherosclerosis (P=0.034).
Conclusion: Our results showed that a significant relationship exists between increased concentration of serum osteocalcin and coronary artery atherosclerosis. However, no such a relationship was observed between the serum levels of K2 and atherosclerotic arteries.
Materials and Methods: This case-control study enrolled 138 people presenting to Bushehr Heart Center for routine examination. Demographic information of the participants was registered in a standard questionnaire. Before undergoing angiography, 10 ml blood was collected from all the participants and stored at – 80 ˚C until the analysis. After the angiography, those who were found to be normal entered the control group, and those with one or more arteries blocked were placed in the case group. Finally, serum levels of vitamin K2 and osteocalcin were measured in all the samples using ELISA kits.
Results: Serum levels of osteocalcin in the case group were significantly higher than those of the control (P=0.019). There was no difference in K2 levels between the two groups (P=0.84). Moreover, no relationship was found between the osteocalcin levels and the number of blocked arteries and the severity of atherosclerosis (P=0.95). By adjusting age and type 2 diabetes in both groups, a difference was observed in the concentration of osteaocalcin and coronary artery atherosclerosis (P=0.034).
Conclusion: Our results showed that a significant relationship exists between increased concentration of serum osteocalcin and coronary artery atherosclerosis. However, no such a relationship was observed between the serum levels of K2 and atherosclerotic arteries.
Type of Study: Original |
Subject:
Cardiovascular System
Received: 2018/02/28 | Accepted: 2018/06/11 | Published: 2018/11/3
Received: 2018/02/28 | Accepted: 2018/06/11 | Published: 2018/11/3
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