Volume 22, Issue 6 (Iranian South Medical Journal 2020)
Iran South Med J 2020, 22(6): 432-450 |
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Tavakoli A, Vahdat K, Keshavarz M. Novel Coronavirus Disease 2019 (COVID-19): An Emerging Infectious Disease in the 21st Century. Iran South Med J 2020; 22 (6) :432-450
URL: http://ismj.bpums.ac.ir/article-1-1222-en.html
URL: http://ismj.bpums.ac.ir/article-1-1222-en.html
1- Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , Keshavarz.m@bpums.ac.ir
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran ,
Abstract: (44299 Views)
Background: At the beginning of the New Year 2020, China alerted the world health organization (WHO) to a cluster of unusual pneumonia cases in Wuhan. After extensive speculation, eventually a new species of coronavirus introduced as the causative pathogen of the disease. Coronavirus disease 2019 (COVID-19) is a name for the disease, and the virus that causes it is known SARS-CoV-2. The very rapid spread of the COVID-19 in China and in many other countries has caused fear among people across the world. The novel coronavirus outbreak declared a Public Health Emergency of International Concern on 30 January 2020.
Materials and Methods: Several databases such as PubMed, Scopus, Google scholar, and BioRxiv were searched for publications reporting on the novel coronavirus up to 29 February 2020. Literature searches were performed using keywords including “Coronavirus 2019”, “2019-nCoV”, “COVID-19”, and
“SARS-CoV-2”. Moreover, websites such as the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) were searched to retrieve updated data and statistics regarding the novel coronavirus. We extracted data on the epidemiology, pathogenesis, virology, clinical manifestations, transmission routes, diagnosis, treatment, and prevention measures.
Results: From the 1416 articles identified in the initial search, 53 were remained after title and abstract screening. After full-text review, 37 articles were eligible to include in our study. Incubation period for
COVID-19 is between 2-10 days, according to the World Health Organization (WHO). The case fatality rate in patients infected with SARC-CoV-2 is 4.3%, and the results indicate that the mortality is higher in elderly individuals and patients with chronic conditions including patients with coronary artery disease, diabetes, chronic pulmonary disease, and hypertension. The mortality rate in healthy subjects is less than 1%.
Conclusion: The outbreak caused by the novel coronavirus is larger than the previous human coronaviruses, showing that the SARS-CoV-2 is an extremely contagious virus. However, the mortality rate of COVID-19 is lower than that of other coronaviruses diseases such as SARS or MERS and other viruses like HIV and Ebola. Currently, due to the lack of an effective treatment and vaccine, the best way to deal with the
COVID-19 disease is to prevent transmission and spread of the virus and to execute personal protective measures.
Materials and Methods: Several databases such as PubMed, Scopus, Google scholar, and BioRxiv were searched for publications reporting on the novel coronavirus up to 29 February 2020. Literature searches were performed using keywords including “Coronavirus 2019”, “2019-nCoV”, “COVID-19”, and
“SARS-CoV-2”. Moreover, websites such as the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) were searched to retrieve updated data and statistics regarding the novel coronavirus. We extracted data on the epidemiology, pathogenesis, virology, clinical manifestations, transmission routes, diagnosis, treatment, and prevention measures.
Results: From the 1416 articles identified in the initial search, 53 were remained after title and abstract screening. After full-text review, 37 articles were eligible to include in our study. Incubation period for
COVID-19 is between 2-10 days, according to the World Health Organization (WHO). The case fatality rate in patients infected with SARC-CoV-2 is 4.3%, and the results indicate that the mortality is higher in elderly individuals and patients with chronic conditions including patients with coronary artery disease, diabetes, chronic pulmonary disease, and hypertension. The mortality rate in healthy subjects is less than 1%.
Conclusion: The outbreak caused by the novel coronavirus is larger than the previous human coronaviruses, showing that the SARS-CoV-2 is an extremely contagious virus. However, the mortality rate of COVID-19 is lower than that of other coronaviruses diseases such as SARS or MERS and other viruses like HIV and Ebola. Currently, due to the lack of an effective treatment and vaccine, the best way to deal with the
COVID-19 disease is to prevent transmission and spread of the virus and to execute personal protective measures.
Type of Study: Review |
Subject:
Communicable Diseases
Received: 2020/02/25 | Accepted: 2020/02/29 | Published: 2020/03/4
Received: 2020/02/25 | Accepted: 2020/02/29 | Published: 2020/03/4
References
1. Khan N. New Virus Discovered By Chinese Scientists Investigating Pneumonia Outbreak. (Accessed Jan 8, 2020, at https://www.wsj.com/articles/new-virusdiscovered-by-chinese-scientists-investigatingpneumonia-outbreak-11578485668)
2. Gralinski LE, Menachery VD. Return Of The Coronavirus: 2019-Ncov. Viruses 2020; 12(2): 135.
3. Novel 2019 Coronavirus Genome. virological.org. (Accessed January 19, 2020, at http://virological.org/t/novel-2019- coronavirus-genome/319)
4. GSAID Database. 2020 Coronavirus. (Accessed January 19, 2020, at Https://Www.Gisaid.Org)
5. Novel Coronavirus—Japan (Ex-China). World Health Organization. Novel Coronavirus— Japan (Ex-China). (Accessed January 19, 2020, at https://www.who.int/csr/don/16-january2020-novel-coronavirus-japan-ex-china/en/)
6. Novel Coronavirus – China. World Health Organization. (Accessed January 12, 2020, at https://www.who.int/csr/don/12-january-2020- novel-coronavirus-china/en/)
7. Lai CC, Shih TP, Ko WC, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) And Corona Virus Disease-2019 (COVID-19): The Epidemic And The Challenges. Int J Antimicrob Agents (In press) 2020; 105924.
8. Gorbalenya EA, Baker SC, Baric RS, et al. Severe Acute Respiratory Syndrome-Related Coronavirus–The Species And Its Viruses, A Statement Of The Coronavirus Study Group. Biorxiv. In press 2020.
9. International Committee on Taxonomy of Viruses ICTV. (Accessed January 19, 2020, at https://talk.ictvonline.org/)
10. Wu A, Peng Y, Huang B, et al. Genome Composition And Divergence Of The Novel Coronavirus (2019-Ncov) Originating In China. Cell Host Microbe (In press) 2020; S1931-3128(20)30072-X.
11. Lam TTY, Shum MHH, Zhu HC, et al. Identification Of 2019-nCoV Related Coronaviruses In Malayan Pangolins In Southern China. Biorxiv. In press 2020.
12. Lu R, Zhao X, Li J, et al. Genomic Characterisation And Epidemiology Of 2019 Novel Coronavirus: Implications For Virus Origins And Receptor Binding. Lancet 2020; 395(10224): 565-74.
13. Zhang L, Shen F, Chen F, et al. Origin And Evolution Of The 2019 Novel Coronavirus. Clin Infect Dis (In press) 2020.
14. China Focus: Pangolins A Potential Intermediate Host Of Novel Coronavirus: Study. Xinhuanet. (Accessed February 7, 2020, at http://www.xinhuanet.com/english/2020- 02/07/c_138764153.htm)
15. Zhou P, Yang XL, Wang XG, et al. Discovery Of A Novel Coronavirus Associated With The Recent Pneumonia Outbreak In Humans And Its Potential Bat Origin. Biorxiv. In press 2020.
16. Li Q, Guan X, Wu P, et al. Early Transmission Dynamics In Wuhan, China, Of Novel Coronavirus–Infected Pneumonia. New Engl J Med (In press) 2020.
17. World Health Organization. Novel Coronavirus(2019-Ncov) Situation Report-7. (Accesses January 27, 2020, at https://www.who.int/docs/defaultsource/coronaviruse/situationreports/20200127-sitrep-7-2019-ncov.pdf)
18. China's National Health Commission News Conference On Coronavirus. New York Times. (Accesses January 26, 2020, at https://www.nytimes.com/2020/01/26/world/c hina-coronavirus.html)
19. Symptoms Of Novel Coronavirus (2019-Ncov). CDC. (Accessed February 29, 2020, at https://www.cdc.gov/coronavirus/2019- ncov/about/symptoms.html)
20. Bai Y, Yao L, Wei T, et al. Presumed Asymptomatic Carrier Transmission Of COVID19. J Am Med Assoc. Available from: URL: https://jamanetwork.com/journals/jama/fullarticle/ 2762028
21. Coronavirus Incubation Could Be As Long As 27 Days, Chinese Provincial Government Says. Reuters. (Accesses Feb 22, 2020, at https://www.reuters.com/article/us-chinahealth-incubation/coronavirus-incubationcould-be-as-long-as-27-days-chineseprovincial government-saysidUSKCN20G06W)
22. Yang Y, Lu Q, Liu M, et al. Epidemiological And Clinical Features Of The 2019 Novel Coronavirus Outbreak In China. Medrxiv. In press 2020.
23. Heymann DL, Shindo N. COVID-19: What Is Next For Public Health?. Lancet 2020; 395(10224): 542-45.
24. Zu ZY, Jiang MD, Xu PP, et al. Coronavirus Disease 2019 (COVID-19): A Perspective From China. Radiology (In press) 2020; 200490.
25. Huang C, Wang Y, Li X, et al. Clinical Features Of Patients Infected With 2019 Novel Coronavirus In Wuhan, China. Lancet 2020; 395(10223): 497-506.
26. Chen N, Zhou M, Dong X, et al. Epidemiological And Clinical Characteristics Of 99 Cases Of 2019 Novel Coronavirus Pneumonia In Wuhan, China: A Descriptive Study. Lancet 2020; 395(10223): 507-13.
27. Wong C, Lam C, Wu A, et al. Plasma Inflammatory Cytokines And Chemokines In Severe Acute Respiratory Syndrome. Clin Exp Immunol 2004; 136(1): 95-103.
28. Neumann C, Scheffold A, Rutz S. Functions And Regulation Of T Cell-Derived Interleukin-10. Semin Immunol 2019; 44: 101344.
29. Jaillon S, Berthenet K, Garlanda C. Sexual Dimorphism In Innate Immunity. Clin Rev Allergy Immunol 2019; 56(3): 308-21.
30. Libert C, Dejager L, Pinheiro I. The X Chromosome In Immune Functions: When A Chromosome Makes The Difference. Nat Rev Immunol 2010; 10(8): 594-604.
31. Sun P, Qie S, Liu Z, et al. Clinical Characteristics Of 50466 Patients With 2019-Ncov Infection. Medrxiv. In press 2020.
32. Xu J, Zhao S, Teng T, et al. Systematic Comparison Of Two Animal-To-Human Transmitted Human Coronaviruses: SARS-Cov2 And SARS-Cov. Viruses 2020; 12(2): e244.
33. Al Awaidy ST, Khamis F. Middle East Respiratory Syndrome Coronavirus(MERS-Cov) In Oman: Current Situation And Going Forward. Oman Med J 2019; 34(3): 181-3.
34. Wu Z, Mcgoogan JM. Characteristics Of And Important Lessons From The Coronavirus Disease 2019 (COVID-19) Outbreak In China: Summary Of A Report Of 72 314 Cases From The Chinese Center For Disease Control And Prevention. J Am Med Assoc. In press 2020.
35. Wu YC, Chen CS, Chan YJ. Overview Of The 2019 Novel Coronavirus (2019-Ncov): The Pathogen Of Severe Specific Contagious Pneumonia (SSCP). J Chin Med Assoc. In press 2020.
36. Chan JFW, Yuan S, Kok KH, et al. A Familial Cluster Of Pneumonia Associated With The 2019 Novel Coronavirus Indicating Person-ToPerson Transmission: A Study Of A Family Cluster. Lancet 2020; 395(10223): 514-23.
37. Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics Of 2019 Novel Coronavirus Infection In China. Medrxiv. In press 2020.
38. Chen H, Guo J, Wang C, et al. Clinical Characteristics And Intrauterine Vertical Transmission Potential Of COVID-19 Infection In Nine Pregnant Women: A Retrospective Review Of Medical Records. Lancet 2020. Available from: URL: https://www.thelancet.com/journals/lancet/arti cle/PIIS0140-6736(20)30360-3/fulltext
39. Coronavirus Disease 2019 (COVID-19). CDC. (Accessed February 28, 2020, at https://www.cdc.gov/Coronavirus/2019- Ncov/About/Transmission.Html)
40. Holshue ML, Debolt C, Lindquist S, et al. First Case Of 2019 Novel Coronavirus In The United States. New Engl J Med 2020.
41. Liu Y, Gayle AA, Wilder-Smith A, et al. The Reproductive Number Of COVID-19 Is Higher Compared To SARS Coronavirus. J Travel Med 2020.
42. Chen J. Pathogenicity And Transmissibility Of 2019-Ncov—A Quick Overview And Comparison With Other Emerging Viruses. Microbes Infect. In press 2020.
43. World Health Organization. Coronavirus Disease 2019(COVID-19): Situation Report-30. (Accesses February 19, 2020, at Https://Www.Who.Int/Docs/DefaultSource/Coronaviruse/SituationReports/20200219-Sitrep-30-Covid19.Pdf?Sfvrsn=6e50645_2)
44. Alshahrani MS, Sindi A, Alshamsi F, et al. Extracorporeal Membrane Oxygenation For Severe Middle East Respiratory Syndrome Coronavirus. Ann Intensive Care 2018; 8(1): 3.
45. Chu CM, Cheng VC, Hung IF, et al. Role Of Lopinavir/Ritonavir In The Treatment Of SARS: Initial Virological And Clinical Findings. Thorax 2004; 59(3): 252-6.
46. Arabi YM, Alothman A, Balkhy HH, et al. Treatment Of Middle East Respiratory Syndrome With A Combination Of LopinavirRitonavir And Interferon-Β1b (MIRACLE Trial): Study Protocol For A Randomized Controlled Trial. Trials 2018; 19(1): 81.
47. Lim J, Jeon S, Shin HY, et al. Case Of The Index Patient Who Caused Tertiary Transmission Of Coronavirus Disease 2019 In Korea: The Application Of Lopinavir/Ritonavir For The Treatment Of COVID-19 Pneumonia Monitored By Quantitative RT-PCR. J Korean Med Sci 2020; 35(6): e79.
48. Mulangu S, Dodd LE, Davey Jr RT, et al. A Randomized, Controlled Trial Of Ebola Virus Disease Therapeutics. New Engl J Med 2019; 381(24): 2293-303.
49. Kirchdoerfer RN, Ward AB. Structure Of The SARS-Cov Nsp12 Polymerase Bound To Nsp7 And Nsp8 Co-Factors. Nat Commun 2019; 10(1): 1-9.
50. Gao J, Tian Z, Yang X. Breakthrough: Chloroquine Phosphate Has Shown Apparent Efficacy In Treatment Of COVID-19 Associated Pneumonia In Clinical Studies. Biosci Trends. In press 2020.
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