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:: Volume 18, Issue 2 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(2): 469-485 Back to browse issues page
Marine natural products in prevention and treatment of osteoporosis
Zahra Ghanbari1, Iraj Nabipour2, Maryam Farrokhnia 3
1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr. Iran
3- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr. Iran , Farrokhnia.m@gmail.com
Abstract:   (3832 Views)

Undoubtedly, pharmaceutical and nutritional factors play an important role in the prevention of age-related bone loss. According to the several studies so far, the effects of nutrients and bioactive components which are extracted from marine resources are very promising in osteoporosis. Most of these investigations have been done on various marine algae extracts. Since, algae are rich source of essential minerals, primary and secondary unique natural products, several amino acids and growth factors their extracts show favorable effects on bone metabolism. Moreover, it has been shown that marine nutrients such as marine fishes, shrimp and crabs increase the absorption of calcium and bone collagen synthesis or reduce the production of prostaglandins and decrease the deoxypyridinoline disposal. On the other hand, secondary products which are extracted and characterized from marine organisms such as mollusks, fungi, bacteria, sponges and coral reefs show anti-osteoporosis activities via the inhibition of osteoclast differentiation and the induction of apoptosis in osteoclasts like cells or stimulation of osteoblast differentiation. Although, several investigations have been done in this area, many of studies have been carried out on animal models, like ovariectomy-induced bone loss in mice. Hence, clinical investigations are warranted to develop marine natural products against bone loss and to prevent osteoporosis.

Keywords: Osteoporosis, Natural product, Marine orgnasim, Sponge, Algae extract
Full-Text [PDF 792 kb]   (2693 Downloads)    
Type of Study: Original | Subject: General
Received: 2015/05/3 | Accepted: 2015/05/3 | Published: 2015/05/3
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Ghanbari Z, Nabipour I, Farrokhnia M. Marine natural products in prevention and treatment of osteoporosis. Iran South Med J. 2015; 18 (2) :469-485
URL: http://ismj.bpums.ac.ir/article-1-691-en.html


Volume 18, Issue 2 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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