[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 18, Issue 3 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(3): 486-496 Back to browse issues page
The effect of Aqueous Purslane (Portulaca Oleracea) Extract on Renal Ischemia/Reperfusion Injury in Rat
Syead Reza Fatemi Tabatabaei1, Majid Askaripour 2, Forozan Hosseini3, Hossein NajafzadehVarzi4
1- Department of physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
2- Department of physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran , askaripour-m@mscstu.scu.ac.ir
3- Department of physiology, Kurdistan University of medical sciences, Sanandaj, Iran
4- Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
Abstract:   (3887 Views)

Background: According to the previous studies Portulaca oleracea (PO) has antioxidative effects and several factors such as oxidative stress is involved in the renal injury caused by ischemia - reperfusion (I/R). Therefore, the goal of present study is to evaluate the renal I/R injury in rats received aqueous extracts of PO (AEPO). Material and Methods: First, the right nephrectomy was performed in adult male Wistar rats and after 20 days they were divided into 5 groups (6=n). Sham operated+vehicle (sham), sham operated+ AEPO300mg/kg (AEPO group), I/R, AEPO150+I/R and AEPO300+I/R. Each group was treated orally for 5 consecutive days by 150 or 300 mg/kg of either AEPO or saline. On the fifth day of treatment, I/R (45 min ischemia/24 hours reperfusion) or sham operation was performed on the left kidney and amounts of urea and creatinine in serum and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and total antioxidant activity (TAA) in the kidney tissue were measured. Comparisons between groups were analyzed by ANOVA and LSD test. P values of 0.05 or less were considered statistically significant. Results: Induction of I/R increased urea and creatinine levels. AEPO had no effect on serum urea and creatinine, of non-ischemic animals, but increased the levels of urea and creatinine in I/R and treatment groups. SOD activity was significantly higher in all groups (except AEPO300 group) compared to the sham group. However the levels of MDA, GSH and TAA of I/R and treatment groups did not show any significant differences in comparison to sham group. Conclusion: According to the results of this study, the PO aqueous extract did not ameliorate the I/R injury and even possibly some ingredients in the extract aggravate the renal I/R injury.

Keywords: Portulaca oleracea, I/R injury, kidney, rat
Full-Text [PDF 485 kb]   (1059 Downloads)    
Type of Study: Original | Subject: Urogenital System
Received: 2015/06/28 | Accepted: 2015/06/28 | Published: 2015/06/28
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fatemi Tabatabaei S R, Askaripour M, Hosseini F, NajafzadehVarzi H. The effect of Aqueous Purslane (Portulaca Oleracea) Extract on Renal Ischemia/Reperfusion Injury in Rat. Iran South Med J. 2015; 18 (3) :486-496
URL: http://ismj.bpums.ac.ir/article-1-695-en.html


Volume 18, Issue 3 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.07 seconds with 31 queries by YEKTAWEB 3961