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:: Volume 6, Number 2 (Iranian south medical of journals 2004) ::
Iran South Med J 2004, 6(2): 97-103 Back to browse issues page
Isolation and purification of a novel anticancer 60 K daltons protein from the Persian Gulf sea hare, Aplysia Dactylomela
Mr Keyvan Zandi *1, Mr Mohammad Hojat farsangi2, Mr Iraj Nabipour3, Mr Masood Soleimani4, Mr Khosro Khajeh5, Mr Reza Sajedi4, Mr Seyed Mojtaba Jafary6, Mr Abbas Ghadery5
1- Assistant Professor , zandi@dr.com
2- msc
3- Assistant Professor
4- PHD
5- Professor
6- MSC
Abstract:   (13148 Views)
Sea hares have attracted the interest of many workers investigating chemical defense substances. Most of these substances are low molecular weight compounds derived from algal diets. Anticancer effects of a novel protein isolated from purple fluid of A. dactylomela are reported. The purification procedure consisted basically of ammonium sulphate fractionation, ion exchange and ultrafiltration techniques. For cytotoxicity effects, L929, K562, HL60 and NB4 cell lines and MTT assay were used. A protein of 60000 Da of the purple fluid of A. dactylomela had antiproliferative effects on the cell lines it was maximally active at 0.5-1.5 microgram/ml on NB4 cell line. Therefore, the purple fluid of A. dactylomela has a novel antiproliferative agent.
Keywords: Sea hare, anticancer, cancer, neoplastic
Full-Text [PDF 39 kb]   (1277 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/01/21 | Accepted: 2009/01/21 | Published: 2009/01/21
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Zandi K, farsangi M H, Nabipour I, Soleimani M, Khajeh K, Sajedi R, et al . Isolation and purification of a novel anticancer 60 K daltons protein from the Persian Gulf sea hare, Aplysia Dactylomela . Iran South Med J. 2004; 6 (2) :97-103
URL: http://ismj.bpums.ac.ir/article-1-113-en.html
Volume 6, Number 2 (Iranian south medical of journals 2004) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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