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:: Volume 23, Issue 3 (Iranian South Medical Journal 2020) ::
Iran South Med J 2020, 23(3): 205-221 Back to browse issues page
Histological and Histometrical Study of Prostate Following Administration of Sertraline in Adult Mice
Hassan Morovvati1 , Mohammadkazem Koohi1, Zabihollah Khaksar2, Freshteh Morshedi1, Hojat Anbara1, Fatemeh Parsaei1, Mehdi Hadijafari1, Hamidreza Moradi 3
1- Department of Basic Sciences, School of Veterinary Medicine, University of Tehran, Tehran- Iran
2- Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
3- Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran , hr.moradi@shirazu.ac.ir
Abstract:   (237 Views)
Background: Sertraline, along with its beneficial antidepressant effects, may have adverse effects on the fertility and reproductive system. In recent years, the negative effects of sertraline on body tissues have been shown to some extent. This study aimed to investigate the effects of sertraline at different doses on the histological and histometrical structure of ventral and anterior lobes of prostate in adult mice.
Materials and Methods: In this experimental study, twenty adult male mice were randomly divided into four groups: control (no treatment) and three groups receiving sertraline at doses of 5, 10 and 20 mg/kg by gavage for 42 days. First, the mice were sacrificed, then, blood samples and prostate lobes tissue were collected for histomorphological and histochemical studies.
Results: Results showed a significant decrease in cell count of secretory units in ventral and anterior lobes in the sertraline groups, compared to that in control group (p<0.05). Epithelial thickness showed a significant decrease in ventral and anterior lobes of prostate following the administration of sertraline (20 mg/kg), compared to the control group (p<0.05). A significant dose-dependent decrease was seen in serum testosterone in sertraline groups, compared to the control group (p<0.05).
Conclusion: Sertraline has a negative effect on the histopathological and histometrical structure of prostate. However, further clinical studies are required to assess the negative effects of sertraline in human beings.
Keywords: Sertraline, Prostate, Histology, Mouse
Full-Text [PDF 1434 kb]   (91 Downloads)    
Type of Study: Original | Subject: Clinical Laboratory Pathology
Received: 2019/11/26 | Accepted: 2020/02/5 | Published: 2020/07/27
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Morovvati H, Koohi M, Khaksar Z, Morshedi F, Anbara H, Parsaei F, et al . Histological and Histometrical Study of Prostate Following Administration of Sertraline in Adult Mice. Iran South Med J. 2020; 23 (3) :205-221
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Volume 23, Issue 3 (Iranian South Medical Journal 2020) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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