[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 13, Issue 2 (Iranian South Medical Journal 2010) ::
Iran South Med J 2010, 13(2): 86-92 Back to browse issues page
Study of Serum Leptin and Ghrelin Levels in Thalassemia Major,
Hamdolah Karamifar Mr, Maryam Bahmanyar Mrs 1, Mehran Karimi Mr
1- , Maryam.Bahmanyar60@gmail.com
Abstract:   (15449 Views)
Background: Endocrine dysfunction related to toxic side effects of iron overload, such as delayed puberty, short stature and hypogonadism present major problems in thalassemic patients. This study was aimed to assess the Leptin and Ghrelin serum levels in such cases. Methods: 50 normal subjects, 50 cases of -thalassemia major and also 50 pateints of thalassemia intermedia were randomly selected and leptin and Ghrelin serum levels were checked. Results: Mean leptin concentration was 2.62±1.2 g/L in patients with - thalassemia major, and 2.878±2.4 g/L in patients with thalassemia intermedia. These values appeared to be significantly lower than in controls (9.228±2.9) (p <0.001). Mean Ghrelin concentrations were 1042.192±275.9 pg/mL and 989.39±275.5 pg/mL in -thalassemia major and intermediate respectively. This value in thalassemia major appeared to be significantly higher compared with controls (876.96±384.3 pg/m) (P<0.01). There was positive relation between circulating leptin and body mass index in thalassemia major and intermediate. Leptin levels were lower in thalassemia major patients with short stature group compared with controls but there was not any correlation between ghrelin levels and short stature in different groups. Conclusion: These results suggest that one of the endocrinopathies affecting thalassemic patients is adipose tissue dysfunction and it seems that low leptin levels play a role in the endocrine dysfunctions in these patients. These findings should be confirmed in further studies.
Keywords: leptin, ghrelin, β thalassemia, short stature
Full-Text [PDF 193 kb]   (1460 Downloads)    
Type of Study: Original | Subject: General
Received: 2010/05/8 | Accepted: 2010/05/8 | Published: 2010/05/8
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Karamifar H, Bahmanyar M, Karimi M. Study of Serum Leptin and Ghrelin Levels in Thalassemia Major,. Iran South Med J. 2010; 13 (2) :86-92
URL: http://ismj.bpums.ac.ir/article-1-210-en.html


Volume 13, Issue 2 (Iranian South Medical Journal 2010) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4050