Volume 28, Issue 6 (Iran South Med J 2026)
Iran South Med J 2026, 28(6): 901-910 |
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Rastegar R, Amiri B, Javaherinasab M, Abbasi F. A Comparative Study of COVID-19 Pneumonia Severity in Vaccinated and Unvaccinated Patients Hospitalized at Persian Gulf Martyrs Hospital, Bushehr, 2021. Iran South Med J 2026; 28 (6) :901-910
URL: http://ismj.bpums.ac.ir/article-1-2468-en.html
URL: http://ismj.bpums.ac.ir/article-1-2468-en.html
1- Department of Infectious Disease, school of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- Clinilcal Research Development Center, The Persian Gulf Martyrs Hospital, Bushehr University of Medical Sciences, Bushehr, Iran
3- Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Infectious Disease, school of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran ,abbasi.f@bpums.ac.ir
2- Clinilcal Research Development Center, The Persian Gulf Martyrs Hospital, Bushehr University of Medical Sciences, Bushehr, Iran
3- Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Infectious Disease, school of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran ,
Abstract: (195 Views)
Backgrounds: SARS-CoV-2 emerged in late 2019 and led to the global COVID-19 pandemic with widespread health, social, and economic consequences. This study aimed to evaluate the effectiveness of COVID-19 vaccination in reducing the severity of viral pneumonia among vaccinated versus unvaccinated patients hospitalized at of the Persian Gulf Martyrs Hospital in Bushehr.
Materials and Methods: This retrospective cross-sectional study was conducted during the second half of 2021 at of the Persian Gulf Martyrs Hospital. Chest CT scans of 221 symptomatic COVID-19 patients, confirmed by RT-PCR, were analyzed. Statistical analysis was performed using SPSS version 26.
Results: The findings revealed that patients with complete COVID-19 vaccination had significantly lower pulmonary involvement on HRCT (P=0.00001). Complete vaccination (at least two doses) was also associated with a significantly reduced risk of ICU admission (P=0.023) and shorter ICU stays (P=0.022). Although the mortality rate was lower in fully vaccinated individuals (4.6%) compared to partially vaccinated (7.4%) and unvaccinated patients (13.7%), the difference was not statistically significant (P=0.123).
Conclusion: Full vaccination against SARS-CoV-2 was associated with reduced pneumonia severity, lower ICU admission rates, decreased oxygen requirement, and shorter hospital stays. This protective effect was more pronounced in patients under 45 years of age compared to older age groups.
Materials and Methods: This retrospective cross-sectional study was conducted during the second half of 2021 at of the Persian Gulf Martyrs Hospital. Chest CT scans of 221 symptomatic COVID-19 patients, confirmed by RT-PCR, were analyzed. Statistical analysis was performed using SPSS version 26.
Results: The findings revealed that patients with complete COVID-19 vaccination had significantly lower pulmonary involvement on HRCT (P=0.00001). Complete vaccination (at least two doses) was also associated with a significantly reduced risk of ICU admission (P=0.023) and shorter ICU stays (P=0.022). Although the mortality rate was lower in fully vaccinated individuals (4.6%) compared to partially vaccinated (7.4%) and unvaccinated patients (13.7%), the difference was not statistically significant (P=0.123).
Conclusion: Full vaccination against SARS-CoV-2 was associated with reduced pneumonia severity, lower ICU admission rates, decreased oxygen requirement, and shorter hospital stays. This protective effect was more pronounced in patients under 45 years of age compared to older age groups.
Type of Study: Original |
Subject:
infectious
Received: 2025/12/25 | Accepted: 2026/04/25 | Published: 2026/06/10
Received: 2025/12/25 | Accepted: 2026/04/25 | Published: 2026/06/10
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