[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Issue 5 (Iranian South Medical Journal 2014) ::
Iran South Med J 2014, 17(5): 824-833 Back to browse issues page
Association of Interferon-alpha and bone density in patients with hepatitis C
Abbas Arj1, Kamal Esalatmanesh2, Seyed AliReza Moravveji3, Shahrzad Karimi4, Eman Ghaffarpasand 5
1- Department of Gastroenterology, Shahid Beheshti Hospital, Kashan, IRAN
2- Department of Rheumatology, Shahid Beheshti Hospital, Kashan, IRAN
3- Department of Community Medicine, School of Medicine, Kashan University of Medical Sciences, Kashan, IRAN
4- Department of Internal Medicine, Shahid Beheshti Hospital, Kashan, IRAN
5- Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IRAN , ghaffarpasand@yahoo.com
Abstract:   (3001 Views)

Background: Chronic hepatitis is a variety of liver dysfunctions with different causes and severities in which inflammation and necrosis last for at least six months. Choice treatment for all chronic viral hepatitis is interferon Alpha (IFN-α). Decreasing bone mass density (BMD) may lead to some complications such as non-traumatic spontaneous fractures. Regarding the decreased bone mass complications and existed dilemma, we conducted the current study to compare the BMD in chronic hepatitis patients before and after the IFN-α treatment. Material and Methods: In a cohort study a total of 22 patients with chronic C- hepatitis needed to be treated with IFN-α were evaluated. All the patients underwent bone mineral densitometry at lumbar spine and femoral neck before and six months after the IFN-α treatment. The BMD result was recorded in information sheet. After the treatment, patients were evaluated again by BMD. All the necessary information such as age, sex, co-morbidity and another medication history were asked and recorded. IFN-α dosage was three million IU three times a week. The gathered data were entered SPSS version 14 and analyzed through Chi-Square and Wilcoxon tests to compare the means. Results: Among 22 patients 21 (95.5%) were male. Mean age was 34.04±7.83 years and half of the patients were in 30 to 35 years age group. The participants had not significant difference in bone mass density indices (Z-score and T-score) before and after treatment with IFN-α (P-value>0.05). The bone mass density indices had not significant difference between different age groups of hepatitis C patients before and after treatment with IFN-α (P-value>0.05). Conclusion: In the current study IFN-α used in the treatment of patients with hepatitis C, had no significant effect on both femoral neck and lumbar spine BMD in them. To evaluate the long term effects of IFN-α it is suggested to do more studies with longer duration, however, the BMD may improve when the inflammation been alleviated long term.

Keywords: hepatitis C, Interferon alpha (IFN-α), Bone Mass Density (BMD), chronic
Full-Text [PDF 503 kb]   (1133 Downloads)    
Type of Study: Original | Subject: General
Received: 2014/10/15 | Accepted: 2014/10/15 | Published: 2014/10/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Arj A, Esalatmanesh K, Moravveji S A, Karimi S, Ghaffarpasand E. Association of Interferon-alpha and bone density in patients with hepatitis C. Iran South Med J. 2014; 17 (5) :824-833
URL: http://ismj.bpums.ac.ir/article-1-596-en.html


Volume 17, Issue 5 (Iranian South Medical Journal 2014) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3974