[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Issue 6 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 17(6): 1090-1099 Back to browse issues page
Correlation between serum levels of uric acid with bone turnover markers in postmenopausal women
Fariba Karimi1, Firooze Mozhde2, Hussain Darabi2, Mohammadreza Kalantar hormozi2, Samad Akbarzadeh2, Afshin Ostovar3, Majid Assadi4, Katayon Vahdat2, Iraj Nabipour 5
1- The Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IRAN
2- The Persian Gulf Tropical Medicine Research Center, Bushehr university of Medical Sciences, Bushehr, IRAN
3- The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, IRAN
4- The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr , IRAN
5- The Persian Gulf Marine Biotechnology Research Center, Bushehr university of Medical Sciences, Bushehr, IRAN , inabipour@gmail.com
Abstract:   (3464 Views)

Background: There is accumulation evidence regarding the protective role of higher serum uric acid in bone loss and osteoprotic fractures. This effect may arise from its antioxidant properties. The main aim of this study was to investigate serum uric acid in relation to bone turnover markers in postmenopausal women.

Material and methods: A total of 382 postmenopausal women who participated in a prospective study were selected randomly from Bushehr port. Serum uric acid levels and biochemical markers including serum alkaline phosphatase were measured. Circulating levels of CrossLaps, osteocalcin and hsCRP were also measured by ELISA.

Results: Uric acid levels had significant correlation with osteocalcin & alkaline phosphatase. However, no correlation could be found between uric acid and CrossLaps. The correlation between uric acid & osteocalcin (r= 0.25, P=0.0001) & alkaline phosphatase(r=0.12, P=0.019) remained after adjustment with age, BMI & hsCRP.

Conclusion: Serum uric acid had a positive and significant correlation with osteoblastic born turnover markers. Hence, the role of uric acid in osteoblastic function should be investigated.

Keywords: uric acid, osteocalcin, CrossLaps, alkaline phosphatase, menopause
Full-Text [PDF 387 kb]   (1153 Downloads)    
Type of Study: Original | Subject: Musculoskeletal System
Received: 2014/12/18 | Accepted: 2014/12/18 | Published: 2014/12/18
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Karimi F, Mozhde F, Darabi H, Kalantar hormozi M, Akbarzadeh S, Ostovar A, et al . Correlation between serum levels of uric acid with bone turnover markers in postmenopausal women. Iran South Med J. 2015; 17 (6) :1090-1099
URL: http://ismj.bpums.ac.ir/article-1-625-en.html


Volume 17, Issue 6 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.07 seconds with 32 queries by YEKTAWEB 3974