Volume 17, Issue 6 (Iranian South Medical Journal 2015)                   Iran South Med J 2015, 17(6): 1090-1099 | Back to browse issues page

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Karimi F, Mozhde F, Darabi H, Kalantar hormozi M, Akbarzadeh S, Ostovar A, et al . Correlation between serum levels of uric acid with bone turnover markers in postmenopausal women. Iran South Med J 2015; 17 (6) :1090-1099
URL: http://ismj.bpums.ac.ir/article-1-625-en.html
Correlation between serum levels of uric acid with bone turnover markers in postmenopausal women
Fariba Karimi1 , Firooze Mozhde2 , Hussain Darabi2 , Mohammadreza Kalantar hormozi2 , Samad Akbarzadeh2 , Afshin Ostovar3 , Majid Assadi4 , Katayon Vahdat2 , Iraj Nabipour * 5
1- The Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IRAN
2- The Persian Gulf Tropical Medicine Research Center, Bushehr university of Medical Sciences, Bushehr, IRAN
3- The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, IRAN
4- The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr , IRAN
5- The Persian Gulf Marine Biotechnology Research Center, Bushehr university of Medical Sciences, Bushehr, IRAN , inabipour@gmail.com
Abstract:   (6145 Views)

Background: There is accumulation evidence regarding the protective role of higher serum uric acid in bone loss and osteoprotic fractures. This effect may arise from its antioxidant properties. The main aim of this study was to investigate serum uric acid in relation to bone turnover markers in postmenopausal women.

Material and methods: A total of 382 postmenopausal women who participated in a prospective study were selected randomly from Bushehr port. Serum uric acid levels and biochemical markers including serum alkaline phosphatase were measured. Circulating levels of CrossLaps, osteocalcin and hsCRP were also measured by ELISA.

Results: Uric acid levels had significant correlation with osteocalcin & alkaline phosphatase. However, no correlation could be found between uric acid and CrossLaps. The correlation between uric acid & osteocalcin (r= 0.25, P=0.0001) & alkaline phosphatase(r=0.12, P=0.019) remained after adjustment with age, BMI & hsCRP.

Conclusion: Serum uric acid had a positive and significant correlation with osteoblastic born turnover markers. Hence, the role of uric acid in osteoblastic function should be investigated.

Keywords: uric acid, osteocalcin, CrossLaps, alkaline phosphatase, menopause
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Type of Study: Original | Subject: Musculoskeletal System
Received: 2014/10/2 | Accepted: 2014/10/27 | Published: 2014/12/18
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