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:: Volume 8, Issue 2 (Iranian south medical of journals 2006) ::
Iran South Med J 2006, 8(2): 110-118 Back to browse issues page
Effects of Ciprofloxacin on rat Sertoli cells
Arash Khaki Mr 1, Parviz Bazzi Mr, Marefat Ghafari Novin Ms
1- , dr.khaki@iaut.ac.ir
Abstract:   (14632 Views)
Background: Ciprofloxacin is a synthetic antibacterial agent from the fluoroquinolones family with a very broad spectrum against microbial pathogens, especially Gram-negative infectious diseases, which has been approved in more than 100 countries world-wide. This study was planed to identify the histopathological effects of ciprofloxacin on rat Sertoli cells. Methods: Twenty male Wistar rats were selected and randomly divided into two groups control (n=10) and experimental (n=10). The experimental group received 12.5 mg/kg oral ciprofloxacin daily for sixty days. On sixtieth day the testis tissues in both groups were removed and weighted, then prepared for light microscopy and electron microscopy studies. Results: There was a marked decrease in testicular weight, marked accumulation and atrophy of seminiferous tubules of Sertoli cells in experimental group as compared with control group (P<0.05). Conclusion: Ciprofloxacin can induce marked histological alteration in testicular tissue of rat, therefore these histological effects and possibility of producing infertility should be investigated in human subjects.
Keywords: ciprofloxacin, Sertoli cells, testis, rat
Full-Text [PDF 4176 kb]   (2889 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/01/15 | Accepted: 2009/01/15 | Published: 2009/01/15
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Khaki A, Bazzi P, Ghafari Novin M. Effects of Ciprofloxacin on rat Sertoli cells . Iran South Med J. 2006; 8 (2) :110-118
URL: http://ismj.bpums.ac.ir/article-1-65-en.html


Volume 8, Issue 2 (Iranian south medical of journals 2006) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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