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:: Volume 20, Issue 2 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(2): 207-216 Back to browse issues page
The Effect of Crude Extract of Turbo coronatus from the Persian Gulf on Serum Biochemical Parameters and Hematiological Parameters of Rats
Amir Vazirizadeh *1, Gholamhossean Mohebbi2, Iraj Nabipour2
1- The Marine Biology and Fishery Science Department, Persian Gulf Institute, Persian Gulf University, Bushehr,Iran , amirvz@yahoo.com
2- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract:   (5454 Views)

Background: Turbotoxins are marine secondary metabolites that produce in Turbinidae family and were isolated from Japanese Turbo marmorata for the first time. A few research has been done on these metabolites so far. Another species, Turbo coronatus exists in Iran. The main aim of the current project was to investigate some biological effects of the crude extract of Turbo coronatus from the Persian Gulf.

Materials and methods: In this study, 18 rats were selected in three groups including the control group. The experimental groups received ½ and 1/3 lethal doses intravenously and serum levels of liver and muscle enzymes, electrolytes and complete blood counts (CBC) were measured after 24 hours.

Results: The levels of liver and muscle enzymes, amylase, sodium, potassium, calcium, phosphorus, ferrous, haptoglobin, albumin and creatinine were significantly increased in experimental group compared with the control group by injection of crude extract of Turbo coronatus; however, hemoglobin, mean corpuscular volume (MCV), red blood cell count, magnesium, and glucose levels were significantly decreased in the experimental group compared with the control group.

Conclusions: Intravenous injection of ½ and 1/3 lethal doses of the crude extract of Turbo coronatus to rats produced rhabdomyolysis and hepatocytes injury. In addition, the crude extract injection acted as a haematoxin and decreased hemoglobin and MCV.

Keywords: Turbo coronatus, Hemolysis, Rhabdomyolysis, Hepatotoxicity, Persian Gulf
Full-Text [PDF 711 kb]   (1513 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2017/01/29 | Accepted: 2017/03/5 | Published: 2017/04/29
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Vazirizadeh A, Mohebbi G, Nabipour I. The Effect of Crude Extract of Turbo coronatus from the Persian Gulf on Serum Biochemical Parameters and Hematiological Parameters of Rats. Iran South Med J. 2017; 20 (2) :207-216
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