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:: Volume 20, Issue 6 (Iranian South Medical Journal 2018) ::
Iran South Med J 2018, 20(6): 540-552 Back to browse issues page
Effect of Hydroalcoholic Extract of Wheat Sprout On Histology and Histometry Structure of Rat's Prostate Exposed to Lead
Hasan Morovvati1, HamidReza Moradi 2, Mesam Biabani1
1- Department of Basic Science, School of Veterinary Medicine, University of Tehran, Tehran- Iran
2- Department of Basic Science, School of Veterinary Medicine, University of Tehran, Tehran- Iran , hmoradi20@yahoo.com
Abstract:   (1682 Views)
Background: Toxic elements can seriously affect prostate gland function. Lead is one of the most common toxic materials among these elements. On the other hand, herbal medicine such as wheat sprout can be used to reduce the heavy metal toxicities. This study has investigated the effects of wheat sprout extract on histological and histometrical structure of prostate gland in rats exposed to lead acetate.
Materials and Methods: Thirty rats were divided randomly into six groups: G1 (control group) received 1 ml/kg/day of normal saline, G2 group received 20 mg/kg/day of lead acetate, G3 and G4 groups received 100 mg/kg/day and 200 mg/kg/day of wheat sprout extract respectively, G5 and G6 groups  received mixture of 20 mg/kg/day of lead acetate along with100 mg/kg/dayand 200 mg/kg/day of wheat sprout extract
respectively. After 35 days, rats were euthanized and blood and prostate tissue samples were collected for histomorphological and histochemical studies.
Results: Results showed a significant decrease in epithelial height of secretory units (P= 0.02) and percentage of parenchyma to stroma (P= 0.036) in the lead group (G2), compared to control group. On the contrary, a significant increase was seen in epithelial height in the group receiving wheat sprout extract[G4 (200 mg/kg/day)], compared to control group (P= 0.033). Serum concentration of testosterone and antioxidant activity (AOA) showed a significant decrease in the lead group(G2), compared to control group (P< 0.001).
Conclusion: Wheat sprout extract is effective in the healing process of damaged tissue structure in prostate glands in rats exposed to lead acetate.
Keywords: Wheat sprout, lead, prostate, histology, rat
Full-Text [PDF 1038 kb]   (521 Downloads)    
Type of Study: Original | Subject: Urogenital System
Received: 2018/01/7 | Accepted: 2018/01/7 | Published: 2018/01/7
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Morovvati H, Moradi H, Biabani M. Effect of Hydroalcoholic Extract of Wheat Sprout On Histology and Histometry Structure of Rat's Prostate Exposed to Lead. Iran South Med J. 2018; 20 (6) :540-552
URL: http://ismj.bpums.ac.ir/article-1-905-en.html

Volume 20, Issue 6 (Iranian South Medical Journal 2018) Back to browse issues page
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