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:: Volume 21, Issue 1 (Iranian South Medical Journal 2018) ::
Iran South Med J 2018, 21(1): 54-64 Back to browse issues page
Diagnostic Value of Magnetic Resonance Spectroscopy in Differentiation of Benign and Malignat Salivary Gland Tumors in Compari-son with Pathology Results
Lila Aghaghazvini * 1, Hashem Sharifian 2, Sirous Omidi 3, Nasrin Yazdani 4, Soheal Kooraki 3
1- Department of radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran , aghaghazvini.leila@gmail.com
2- Department of radiology, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran
3- Advanced Diagnostic and invasive imaging research center, Tehran University of Medical Sciences, Tehran, Iran
4- ENT research center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (619 Views)
Background: Differentiation between benign and malignant parotid tumors before surgery is important
because it can change the therapeutic planning for patients. In this study we evaluated the role of Magnetic resonance spectroscopy (MRS) in differentiation of benign from malignant parotid tumors.
Materials and Methods: 40 patients entered with salivary gland tumor especially parotid) that candidated for surgery in this study. Patients selected in Amiralam hospital and did MRI in Imam Khomeini hospital. In this study, on these patients Magnetic resonance spectroscopy (MRS) was performed at 135 and 270 Time of Echo, and the choline/creatine ratio was determined. Regarding to the cytological results, patient divided to warthin, benign and malignant tumors and ROC curves used to determine the best cut off points.
Results: 40 patients entered in this study, 25 had benign non warthin tumors, 9 malignant tumors and 6 warthin tumors. In differentiation benign from malignant tumors TE136 was stronger. The best cut off point of Choline to Creatine ratio in TE: 136 was 1.92 with sensitivity 81 % and specificity 89% and in TE 270 was 1.76 with Sensitivity 89% and specificity 71%.  Choline/creatine ratio <1.25 can rule out the malignancy with sensitivity of 92% and ratio > 1.76 strongly suggest malignancy (with10% specificity). MRS was not able to differentiate benign non warthin from warthin tumors.
Conclusion: According to this study, Choline/ creatine ratio in MRSpectroscopy can be helpful as noninvasive method in differentiation of benign from malignant tumors.
Keywords: Tumor, salivary gland, Magnetic resonance spectroscopy, malignant, benign, parotid
Full-Text [PDF 498 kb]   (161 Downloads)    
Type of Study: Original | Subject: Radiology. Diagnostic Imaging
Received: 2018/02/26 | Accepted: 2018/02/26 | Published: 2018/02/26
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Aghaghazvini L, Sharifian H, Omidi S, Yazdani N, Kooraki S. Diagnostic Value of Magnetic Resonance Spectroscopy in Differentiation of Benign and Malignat Salivary Gland Tumors in Compari-son with Pathology Results . Iran South Med J. 2018; 21 (1) :54-64
URL: http://ismj.bpums.ac.ir/article-1-914-en.html

Volume 21, Issue 1 (Iranian South Medical Journal 2018) Back to browse issues page
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