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:: Volume 21, Issue 4 (Iranian South Medical Journal 2018) ::
Iran South Med J 2018, 21(4): 297-303 Back to browse issues page
Comparison of Signal to Noise Ratio in Distor-tion Product Otoacoustic Emission between Human and Rat
Sadegh Jafarzadeh *
Department of Audiology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran , Sjafarzade@gmail.com
Abstract:   (2295 Views)
Background: Distortion product otoacoustic emissions evaluate the function of outer hair cells in the cochlea. The present study aimed to compare distortion product otoacoustic emissions between normal hearing adult human and rat to better understand their differences.
Materials and Methods: In this study, signal to noise ratio of distortion product otoacoustic emissions was evaluated and the results of normal hearing persons (n=60) and rats (n=30) were evaluated in similar conditions at of 2, 3, 4, and 5 KHz.
Results: The difference between the two groups was significant in most frequencies except 3 KHz. In rats, a higher signal to noise ratio was observed at 4 and 5 KHz and a lower ratio at 2 KHz. There was no significant difference among different frequencies in human samples.
Conclusion: Significant differences in distortion product otoacoustic emissions in the two groups may demonstrate the different mechanisms for cochlear function in human and rat. This result may indicate the need for extra cautions in using rats as an animal model.   
Keywords: DPOAE, normal hearing, human, rat.
Full-Text [PDF 329 kb]   (749 Downloads)    
Type of Study: Original | Subject: Radiology. Diagnostic Imaging
Received: 2017/11/5 | Accepted: 2018/02/14 | Published: 2018/09/4
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jafarzadeh S. Comparison of Signal to Noise Ratio in Distor-tion Product Otoacoustic Emission between Human and Rat. Iran South Med J 2018; 21 (4) :297-303
URL: http://ismj.bpums.ac.ir/article-1-940-en.html

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Volume 21, Issue 4 (Iranian South Medical Journal 2018) Back to browse issues page
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