Showing 13 results for Moghadam
Mr Nematollah Razmi, Mr Hamid Kolalian Moghadam, Mr Mohammad Reza Tabandeh, Mr Abolfazl Babakhani,
Volume 10, Issue 2 (Iranian South Medical Journal 2008)
Abstract
Background: Recently, ingestion of shark cartilage has been increased among patients with cancer on the basis of this claim that sharks rarely develop cancer because of their high proportion of cartilage and antiangiogenesis compounds. The goal of this study was to evaluate the antitumor effect of shark cartilage and growth of induced mammary tumors in rat using dimethylbenzanthracene (DMBA) and to assess the improvement in some Quality-of-Life markers. Methods: Tumors were induced by 7, 12 Dimethylbenzanthracene (DMBA) 20mg/2ml corn oil for each rat using gavage method. Cartilage powder was prepared from neural cord of white snout shark (Persian Gulf, Iran).A total of 60 Sprague Dawley rats were divided in two groups (30 rats in each group): pretumor establishment treatment (PRTE) and post tumor establishment treatment (PSTE). Each group was divided in two control (n=15) and treatment (n=15) subgroups. Animals in treatment PRTE (30 days after tumor induction) and PSTE (after palpable tumors were established) groups were treated with 10mg/day /rat shark cartilage for 30 days. Animal weight gaining, tumor induction time, tumor number and size were recorded on induction and 30, 60, 120 and 200 days after induction. Results: There was no significant difference in number and size of tumors between PSTE treatment and PRTE control, two months after treatment (P>0.05), but this difference was significant between PSTE treatment and PSTE control groups (P<0.05). Weight gaining, in treatment period, was higher in PRTE treatment than PRTE control (P<0.05), but this difference was not significant at the end of the treatment (P>0.05). Two months after treatment tumors significantly regressed in PSTE group. At the end of the study, significant difference was shown between PSTE treatment and other groups in weight gaining, number and size of tumors (P<0.05). Conclusion: Mammary tumor induced with DMBA in rat was regressed when shark cartilage was administrated orally and weight gaining mean, as a marker of improvement of quality of life, was better two months after treatment. But shark cartilage did not prevent tumorigenesis. Further studies about proper dosage, clinical complications, efficient prescription methods and level of availability of biological protein products derived from shark cartilage are recommended.
Mr Mehdi Azami, Mr Davod Dorostkar Moghadam,
Volume 11, Issue 1 (Iranian South Medical of Journal 2008)
Abstract
Background: Cryptosporidium is an important enteric parasite which causes diarrheal illness in humans and animals worldwide. With attention to the role of cryptosporidium in producing diarrhea and mortality in immunocopromised patients and children under 5 years of age, the present study was designed to identify the prevalence of cryptosporidium and potential risk factors in Isfahan province. Methods: This descriptive study was done in Isfahan province from October 2003 to April 2004. A total of 642 children under 5 years of age, immunocompromised patients and high risk persons selected randomly and their stool samples were studied microscopically using Sheater's Sucrose Flotation technique and stained by modified Ziehl-Neelsen staining method. Results: The overall prevalence of cryptosporidium was 4.7% (30 samples). The prevalence rates of infection were 4.6%, 3.5% and 5.4% in children under 5 years of age, immunocompromised patients and high risk persons, respectively. The highest prevalence of infection (6.2%) belonged to 1-2 years old children in the group of under 5 years of age, 3-4 years in immunocompromised patients group and 5-10 years in high risk persons group (10%, 6.2% and 14.8% respectively). Conclusion: Cryptosporidium is significantly prevalent in children under 5 years of age, immune compromised patients and high risk persons in Isfahan province. Therefore, health policy makers have to design a plan to identify and treat infected subjected with cryptosporidium thus as a result the transmission of the disease can be prevented in the society.
Mr Seyed Abdolhossein Tabatabaie, Mr Mohammad Reza Asharin, Mr Majid Assadi, Mr Iraj Nabipour, Mr Abdol Ali Ebrahimi, Ms Mojdeh Nasiri Ahmad Abadi, Mr Mansour Moghadam, Mr Mohammadreza Pourbehi,
Volume 12, Issue 3 (Iranian South Medical of Journal 2009)
Abstract
Background: Most patients with acute myocardial infarction with ST-segment elevation (STEMI) are still treated with pharmacological reperfusion which is not always successful. The aim of this study was to determine whether enoxaparin was associated with superior efficacy and safety compared with unfractionated heparin (UFH) in the STEMI setting. Methods: In this clinical trial, 150 patients less than 75 years old (104 men and 46 women) with STEMI who were scheduled to undergo streptokinase (1.5 milion unit per hour) randomly assigned to receive enoxaparin (40 mg intravenous bolus then 1 mg/kg subcutaneously BID) (group 1) or weight adjusted UFH from 24 to 48 hours after streptokinase (group 2). All patients underwent predischarge coronary angiography. Results: A number of 75 patients in group 1 (mean age 58.9 ±9.4) and 75 pateints in 2 (mean age 56.3±9.0) were studied. Two groups were well matched with respect to main risk factors and also other concomitant medications. Time from onset of symptom to start fibrinolysis and myocardial regions infarction were similar in both groups (p=0.13). Left ventricular ejection fraction were 45.2 ± 5.6 % in group 1 and 40.3 ± 7.3 % in group 2 (p=0.056). Major bleeding just was in 2 cases of group 1. Minor bleeding was in 10 cases of group 1 and 5 of group 2 (p>0.05). Conclusion: Our data showed a benefit of Enoxaparin compared with UFH in patients receiving fibrinolysis for STEMI with a mild trend toward an excess of bleeding. However, further well designed studies to assess these results with following patients for a longer period of time and also comparing therapeutic effects are needed.
Elaheh Tekye, Sara Moghadam Nia, Akram Eidi, Reza Taghizadfarid, Roohollah Ferdosi, Jalal Zarringhalam,
Volume 15, Issue 1 (Iranian South Medical of Journal 2012)
Abstract
Background: Different mediators are involved in pain and edema induction during different stages of inflammation. Then, treatment of them encounters some difficulties. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. This study was aimed to investigate anti-inflammatory and analgesic effects of Olea europaea L.methanolic extract on male NMRI mouse. Methods: Methanolic extraction was done for leaf of Olea europaea L. and different doses (200, 300 and 400 mg/kg) were intraperitoneally (i.p.) adminstered to male NMRI mice. Analgesic and anti-inflammatory effects of extract was measured during both phases of Formalin test, Acetic acid induced visceral pain and xylene inflammation tests. A standard analgesic and anti-inflammatory drug such as indomethacin, dexamethasone and morphine were administered in positive control groups where appropriates. Results: Results indicated significant dose-dependent analgesic and anti-inflammatory effects of methanolic extract of Olea europaea L. leaf on pain which induced by formalin (both phase) and acetic acid, and inflammation caused by xylene. Conclusion: Our findings Showed that administration of methanolic extract of Olea europaea L.leaf can suppress pain and inflammation dose dependently which, may mediate via different components of extract. However, more investigations need to be done.
Shadmehr Mirdarharijani , Majid Nejabat , Akbar Hajizadeh Moghadam ,
Volume 16, Issue 2 (Iranian South Medical Journal 2013)
Abstract
Background: The incidence of thrombosis is lower in children and prepubertal period than adults. But its incidence increases in adolescence.The aim of this study was comparing the effect of one session of endurance exhaustive exercise in different times on some of coagulation systems markers in pre and after maturation wistar rats. Material and Methods: 27mature male wistar rats with 241±5 grams mean weight and 27 immature male rats with 97±5 grams mean weight which were 14 and 5 weeks old, respectively, after two weeks getting accustomed to the new environment and treadmill, were divided into one control and two exercising groups. Then, sampling was performed immediately and after 24 hours after exercise. Exhausting endurance exercise program involved increasing the speed of treadmill until getting exhausted. Fibrinogen, APTT, and PT were measured with the Clause and coagulation methods. The analysis was performed by using independent t-test, one-way variance analysis and tukey test. Significance level was assigned for all statistical analysis (p≤0.050). Results: Results in immature and mature rats groups indicated that amounts of fibrinogen has had significant reduction immediately after exercise (p=0.004, p=0.047), and 24 hours after exercise were significantly increased only in mature rats (p=0.000). Also, APTT in all groups decreased immediately and 24 hours after exercise but it was significant just 24 hours after exercise. Conclusion: Due to the increased fibrinogen and decreased APTT at 24 hours after exhaustive endurance exercise in mature and immature rats, it seems that performing such activities in children and inactive adults must be accompanied with special considerations.
Samira Khayat , Masoomeh Kheirkhah , Hamed Fanaei , Zahra Behboodi Moghadam , Masoomeh Pourmohsen , Amir Kasaeiyan ,
Volume 18, Issue 3 (Iranian South Medical Journal 2015)
Abstract
Background: Most women at reproductive ages experience the premenstrual syndrome (PMS). Different methods have been suggested for the treatment of this syndrome and one of them is using herbal medicine. This study was carried out to evaluate the effects of ginger and curcumin on severity of symptoms of PMS. Materials and Methods: In this double-blind clinical trial, 105 students with PMS symptoms were randomly assigned to ginger, curcumin and placebo groups. Participants received two capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded severity of the symptoms by Daily Record of Severity of Problems (DRSP) questionnaire. Data of before interventions and 1, 2 and 3 months after interventions were analyzed by repeated measurement ANOVA and indepented t-test. SPSS-18 software was used for analyses and P<0/05 was considered significant. Results: The mean of PMS symptoms severity were similar in three groups before the intervention [( 110/2±30/7 in ginger group, 103/6±39/1 in curcumin group and106/7±44/65 in placebo group) p=0/79], but after interventions there were significant differences between groups [(47/06 ±33/4 in ginger group, 29/74±11/6 in curcumin group and106±48/7 in placebo group) P<0/0001]. Also, there was a significant difference between effects of curcumin and ginger (P=0/008). Conclusion: Ginger and curcumin are effective in reduction of severity of psychological, physical and behavioral symptoms of PMS and the effect of curcumin is more than ginger. Results of present study suggest curcumin and ginger as treatment for PMS.
Akram Eidi , Zohreh Nateghi , Pezhman Mortazavi , Jalal Zarringhalam Moghadam,
Volume 19, Issue 4 (Iranian South Medical Journal 2016)
Abstract
Background: Licorice (Glycyrrhiza glabra L., Fabaceae) is a well-known herb that it used in traditional medicine due to pharmacological activities. Licorice in herbal medicine is used as a tonic, expectorant and demulcent factor. This plant has antioxidant, immunostimulant, anti-allergenic and anti-ulcer activities. The aim of present study was to, comparisons of effect of ethanol extracts licorice root with glibenclamide on activity of liver enzymes in normal and alloxan-induced diabetic rats.
Materials and Methods: In the present study, oral administration of licorice extract (50, 200 and 400 mg/kg per body wt.) and glibenclamide (600 µg/kg) were performed as the standard antidiabetic medicine, during 30 days. Then, the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in normal and diabetic rats were evaluated. Data were analyzed by using SPSS-10 software and the ANOVA test was used.
Results: Oral administrations of licorice extract significantly decreased activity of AST and ALT in serum of diabetic rats but not in normal rats. The licorice extract as same as glibenclamide significantly decreased activity of liver enzymes.
Conclusion: It is concluded that the licorice can be considered as a suitable candidate for future studies on diabetes mellitus.
Mohammad Reza Ramezani , Hosein Naderi Manesh , Majid Erfani Moghadam ,
Volume 19, Issue 5 (Iranian South Medical Journal 2016)
Abstract
Background: The study of the molecular dynamics of proteins based on internal motions is crucial for understanding the mechanism of protein function. Internal movements of proteins play an important role in both protein folding processes and the mechanism of action of enzyme. Knowledge about these movements will help us in understanding these processes correctly. Osmolites are small organic molecules which are utilized by the cells of all organisms, except hallobacteria. Osmolites are produced under extreme stressful conditions in order to help in stabilizing macro-molecules and retaining their biological function. They interact directly with macromolecules, but they exert their effect only when the characteristics or conditions of the solvent present around the cell change. Therefore, their presence affects the stability of the protein indirectly.
Materials and Methods: In this work we studied the effect(s) of the osmolite Sorbitol on the dynamics of Hen Egg White Lysozyme, and through our study we used NMR Hydrogen-Deuterium Exchange to characterize the effect(s). We performed spectrometery in two different conditions, in the absence and presence of sorbitol. The extent of peptide hydrogen exchange was assigned as a function time and in a decreasing manner in the intensity of the peak corresponding to amino acids. The resulting TOCSY spectra were assigned using SPARKY software, as well as we integrated the peaks using this software.
Results: The speed of hydrogen exchange, hydrogen atoms of the peptide bond, will give us information about the local structural oscillations where the exchange is taking place. The rate of hydrogen exchange varies from one amino acid to another, and the intensity of the peak of these hydrogen decreases as time passes by.
Conclusion: We found that the presence of sorbitol causes a decrease in proton exchange rate, and since there is no noticeable chemical shifts in the peaks of the spectra, in the presence or absence of sorbitol, we can conclude that sorbitol did not cause any change in the three dimensional structure. It seems that the decrease in the rate of exchange is a representative of a decrease in the accessible surface area or to strengthening of hydrogen bonds, and sorbitol caused one of these two possibilities.
Abolfazl Moghadam , Shahram Nazarian ,
Volume 20, Issue 5 (Iranian South Medical Journal 2017)
Abstract
Background: Salmonella are significant bacteria of the Enterobacteriaceae which are very diverse biochemically and serologically. These bacteria are primarily transmitted through food ingestion. The spread of non-typhoid Salmonella is one of the challenging issues in the current medical research. Therefore, rapid diagnosis and identifying the type of these pathogens provide crucial information for early detection and controlling the spread of the infection. The aim of this study was typing the clinical strains of Salmonella Infantis.
Materials and Methods: In this study, strains of Salmonella Infantis were isolated from several health centers. All of the strains were identified by standard microbiology, biochemical and molecular methods. Genetic relationship between strains was analyzed using the ERIC-PCR method.
Results: In this study, 842 stool and blood sample of patients with diarrhea were examined, and 48 different strains linked to Salmonella Infantis were isolated. Strains categorized into 14 different groups by genotyping using the ERIC-PCR method, and the highest number of the strains were placed in group 5 (20%, 10 strains).
Conclusion: Results of this study revealed that strains of Salmonella Infantis which were examined genetically were rather diverse in nature. This could be due to the high prevalence of polyclonal strains in human samples. It was also shown that ERIC-PCR method has an abundant differential power for the molecular typing purposes.
Akram Farhadi, Maryam Noroozian , Farahnaz Mohammadi , Mahshid Foroughan , Maryam Rassouli , Liela Sadeghmoghadam , Shima Nazari ,
Volume 21, Issue 4 (Iranian South Medical Journal 2018)
Abstract
Background: The growing trend of aging population and age-related diseases, such as dementia, stresses the importance of addressing caregiving. One of the notable issues in this area is the positive appraisal of caregivers of their cares, therefore, the present study aimed to explain the positive experiences of family caregivers of older adults with dementia in Iran.
Materials and methods: This qualitative study used conventional content analysis approach. Twelve family caregivers of older adults with dementia were selected through purposeful sampling from among those attending Memory Clinic of Yadman and Alzheimer's Association of Iran in Tehran. and participated in semi-structured interviews. Data were analyzed simultaneously with data collection.
Results: Data analysis led to the emergence of three main categories of satisfaction with care, personal growth and caregiving gains along with nine subcategories, which show the positive appraisal of caregivers of their caregiving.
Conclusion: According to the results of this study, although the results of our study are somewhat similar to those of the western studies, the appraisal of family caregivers of their care has unique dimensions specific to Iranian culture. These positive appraisals can be used to design specific interventions to reduce the negative outcomes of caregiving.
Mehdi Sadeghi , Afsaneh Vahedi Moghadam , Ali Movahed ,
Volume 22, Issue 1 (Iranian South Medical Journal 2019)
Abstract
Background: Portulaca Oleracea is a medicinal plant with many effects including analgesic and anti-inflammatory properties. This study aimed to investigate the effect of alcoholic extract of Portulaca Olerecea on CCI model of neuropathic pain (Bennet & Xie model) and acute thermal pain induced by Tail Flick.
Materials and Methods: Adult male Wistar rats weighing 200-250 g were used. Sensitivity to mechanical stimuli (mechanical allodynia) and noxious thermal stimuli were evaluated by Von Frey filaments and Tail Flick, respectively. In neuropathic pain studies, animals were randomly assigned to five groups of sham, CCI, two groups subjected to CCI and injected with extract (200 and 400 mg/kg, i.p.) and a group subjected to CCI and injected with normal saline. In these groups, mechanical allodynia was assessed on day 7 after surgery. In acute pain studies, animals were divided to three groups of a group that received normal saline and two groups that received extract (200 and 400 mg/kg, i.p.). In these groups, Tail Flick was measured 30 minutes after normal saline or extract administration. Data were analyzed by SPSS and appropriate statistical tests.
Results: All of the rats that had experienced CCI, exhibited mechanical allodynia after neuropathy.Portulaca oleracea could reduce the development of mechanical allodynia after CCI at 200 and 400 mg/kg doses. Thermal acute pain was reduced by 400 mg/kg of the extract.
Conclusion: Our findings indicate that Portulaca Oleracea extract can reduce behavioral symptoms of
neuropathic and acute pain.
Reza Ghasemikhah , Zainab Davudi Moghadam , Fatemeh Ahmadi , Mahsa Rasulpur , Mohammad Reza Bayatiani , Reza Hajihossein , Hossein Sarmadian , Fatemeh Seif ,
Volume 23, Issue 2 (Iranian South Medical Journal 2020)
Abstract
Background: Giardia is one of the infectious agents that can be transmitted by surface water and cause a disease. We designed and fabricated a magnetic system to separate the giardia cysts from water.
Materials and Methods: In this study, giardia cysts were concentrated by sucrose floatation method. The cysts were mixed with physiological saline and their concentration was adjusted to 100,000 cysts per cubic millimeter using Neubauer slide. The isolated cysts were passed through the magnetic field generated by the 200-msT magnets. The cysts were attracted to the magnet and removed from the suspension. The cysts were exposed to magnetic field for one week in order to evaluate the effect of magnetic field on their survival, which was reported as 0.1% using eosin staining under a light microscope.
Results: The results showed that magnetic field can relatively absorb giardia cysts from water, the survival rate of the cysts did not change significantly in different days (P≥0.05).
Conclusion: The designed magnetic system can be reinforced to isolate giardia cysts, which is economical and has no chemical effects on water.
Aida Lotfi , Javad Hamedi , Majid Taati Moghadam , Faramarz Masjidian Jezi,
Volume 26, Issue 3 (Iranian South Medical Journal 2024)
Abstract
Background: Listeria monocytogenes leads to listeriosis in humans through the consumption of ready-to-eat foods. Older adults, immunocompromised patients, pregnant women, and newborns are at the highest risk for this infection. To detect probiotic bacteria with an inhibitory activity against L. monocytogenes, we evaluated the inhibitory effect of Lactococcus lactis on the growth and invasion of L. monocytogenes.
Materials and Methods: In this study, we used the L. monocytogenes ATCC 7644 strain and the L. lactis PTCC 1336 probiotic strain. To investigate the inhibitory effects of L. lactis on the growth of pathogenic L. monocytogenes, we employed the well diffusion agar method, and to investigate its inhibitory effect on invasion by this bacterium, we conducted a co-culture with Caco-2 human enterocyte cells.
Results: The results showed that L. lactis in concentrations of 0.25, 0.5, and 1 had antimicrobial properties against L. monocytogenes. With increasing concentration, the inhibitory effect on this pathogen increased. In addition, L. lactis showed an inhibitory effect on the L. monocytogenes invasion of Caco-2 cells. Therefore, in the concentration of 1, L. lactis decreased the number of bacteria by reducing the invasion of the cells by Listeria from log 108 to log 102; in the concentration of 0.5, from log 108 to log 103; and in the concentration of 0.25, from log 108 to log 105.
Conclusion: L. lactis has antimicrobial and inhibitory properties against the invasion of L. monocytogenes and can be considered an option to inhibit invasion and gastrointestinal infections caused by this bacterium.
