Shadmehr Mirdar Harijani , Narges Musavi , Gholamreza Hamidian,
Volume 18, Issue 1 (Iranian South Medical Journal 2015)
Abstract
Background: The studies have reported that exercise induced apoptosis in various tissues. The abnormal regulation of apoptosis contributes to the progression of pathological processes in the placenta and effects on embryo development. The aim of the present study was to investigate the effect of swimming endurance training during pregnancy on apoptosis induction in pregnant rats' liver. Materials and Methods:: Sixteen female Wistar rats with an average weight of 200 ± 20 grams were divided into two groups: swimming and control. The rats of training group were forced from first day of pregnancy to delivery in a particular pool. The time of training in first day of pregnancy was 10 min and this time in second week reached to 60 min by increasing of 5 min per day. The time of 60 min continued to end of third week. The sampling of the rats' liver was performed two days after delivery and the liver apoptotic index was determined with TUNEL technique. Statistical analysis of the data was done using independent t-test (α≤ 0.05). Results: The results of study showed that swimming endurance training did not induce significant change in liver apoptosis (p < 0.424). The mean of apoptosis in control and training groups was %7.40 and %8.60 respectively. But 3-wk period of swimming training induced significantly minor increase in the amount of post pregnancy weight gain compared to the control group (p < 0.001). In addition, it was observed non-significant decrease in weight of training groups rat's liver compared to the control group (p = 1.00). Conclusion: It seems that endurance swimming training during pregnancy has no anguishing effect on apoptosis induction in liver and it is considered as safe exercise way in the improvement of mother and infant health.
Ali Reza Baneshi , Ardovan Nowroozi Asl , Gholamhosseain Darya , Farid Hashemi , Seyedeh Maryam Musavi ,
Volume 22, Issue 3 (Iranian South Medical Journal 2019)
Abstract
Background: Thyroid dysfunction is one of the controversial complications of diabetes. Given the hypoglycemic properties of Yellow Horne Poppy (YHP), this study was conducted to evaluate the effect of oral administration of aqua-ethanolic extract of YHP and glibenclamide on serum level of T3 and T4 hormones in alloxan diabetic rats compared to healthy rats.
Materials and Methods: In this experimental study, 56 male Wistar rats were randomly divided into seven groups of 8, including healthy control, healthy treated with 250 and 500 mg/kg of YHP extract, diabetic control, diabetic treated with 250 and 500mg/kg of YPH extract and diabetic treated with 5μg/kg of glibenclamide. Diabetes was induced by intraperitoneal injection of a single dose of alloxan. After 30 days of treatment, blood samples were collected and the concentration of thyroid hormones T3 and T4 were measured. Finally, the data were analyzed using one-way ANOVA.
Results: The serum concentrations of thyroid hormones were significantly lower in the diabetic control group than those in the control group (P<0.001). The mean concentration of T3 was significantly higher in the diabetic+250 extract than that in the diabetic control group (P<0.001). Also, the mean concentration of T4 was significantly higher in the diabetic+250 extract than that in the diabetic+drug group (P=0.04).
Conclusion: YPH extract can effectively improve T3 and T4 serum levels in diabetic rats. Further studies are required to determine the active ingredient responsible for this therapeutic effect, such as Glaucin.
