Volume 27, Issue 4 (Iran South Med J 2025)
Iran South Med J 2025, 27(4): 250-257 |
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Ghafouri S, Salehi kahyesh R, Rajaee Behbahani S, Razie S, Alghasi A, Faramarzi M H. Investigating the Role of Myopathy Markers Ex-pression (Creatine Kinase, Aldolase, INF-γ and TNF-α) Following the Use of Chemotherapy Drugs in Children with Leukemia. Iran South Med J 2025; 27 (4) :250-257
URL: http://ismj.bpums.ac.ir/article-1-2090-en.html
URL: http://ismj.bpums.ac.ir/article-1-2090-en.html
Samireh Ghafouri1 
, Roya Salehi kahyesh2 , Shahram Rajaee Behbahani3 , Shiva Razie4 , Arash Alghasi *5 , Mohammad Hosein Faramarzi2
, Roya Salehi kahyesh2 , Shahram Rajaee Behbahani3 , Shiva Razie4 , Arash Alghasi *5 , Mohammad Hosein Faramarzi2
1- Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ah-vaz, Iran
2- Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Department of Pediatrics, Pediatric Cardiology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Department of Histology and Anatomy, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,arashalqasi@ yahoo.com
2- Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Department of Pediatrics, Pediatric Cardiology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Department of Histology and Anatomy, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
Abstract: (323 Views)
Background: Acute lymphoblastic leukemia (ALL) is one of the most common childhood
malignancies with a prevalence of 40 per million children under 15 years old. This study aimed to investigate the expression of myopathic markers following the use of chemotherapeutic agents in children with leukemia and the role of inflammatory cytokines in this disorder.
Materials and Methods: This descriptive-analytical study was conducted on children with ALL with and without symptoms of myopathy who were hospitalized at Shahid Baghaei 2 Hospital. These two groups were compared in terms of aldolase, creatine kinase, tumor necrosis factor (TNF-α), and interferon-gamma (INF-γ) by ELISA. Statistical analysis was performed using SPSS version 22 software.
Results: Of the 40 children with ALL with and without symptoms of myopathy, the mean age was 8.68 ± 3.89 years. There was no significant relationship between inflammatory cytokines and age; however, there was a significant difference in gender between the case and control groups (P=0.047), with inflammatory cytokines being higher in boys than girls. The serum
aldolase level in the case group did not differ significantly from the control group (P=0.947). The serum creatine kinase level was significantly reduced in the case compared to the control group (P=0.009). Also, the serum levels of inflammatory factors TNF-α and INF-γ were not significantly different between the case and control groups.
Conclusion: Since inflammation caused by malignancies is one of the factors causing myopathy, inflammatory markers can be used to evaluate the effectiveness of therapeutic interventions in patients with various types of malignancies.
malignancies with a prevalence of 40 per million children under 15 years old. This study aimed to investigate the expression of myopathic markers following the use of chemotherapeutic agents in children with leukemia and the role of inflammatory cytokines in this disorder.
Materials and Methods: This descriptive-analytical study was conducted on children with ALL with and without symptoms of myopathy who were hospitalized at Shahid Baghaei 2 Hospital. These two groups were compared in terms of aldolase, creatine kinase, tumor necrosis factor (TNF-α), and interferon-gamma (INF-γ) by ELISA. Statistical analysis was performed using SPSS version 22 software.
Results: Of the 40 children with ALL with and without symptoms of myopathy, the mean age was 8.68 ± 3.89 years. There was no significant relationship between inflammatory cytokines and age; however, there was a significant difference in gender between the case and control groups (P=0.047), with inflammatory cytokines being higher in boys than girls. The serum
aldolase level in the case group did not differ significantly from the control group (P=0.947). The serum creatine kinase level was significantly reduced in the case compared to the control group (P=0.009). Also, the serum levels of inflammatory factors TNF-α and INF-γ were not significantly different between the case and control groups.
Conclusion: Since inflammation caused by malignancies is one of the factors causing myopathy, inflammatory markers can be used to evaluate the effectiveness of therapeutic interventions in patients with various types of malignancies.
Type of Study: Original |
Subject:
Musculoskeletal System
Received: 2024/11/23 | Accepted: 2025/02/9 | Published: 2025/03/10
Received: 2024/11/23 | Accepted: 2025/02/9 | Published: 2025/03/10
References
1. Terwilliger T, Abdul-Hay M. Acute lymphoblastic leukemia: a comprehensive review and 2017 update. Blood Cancer J 2017; 7(6): e577-e. [DOI]
2. Park JH, Rivière I, Gonen M, et al. Long-Term Followup of CD19 CAR Therapy in Acute Lymphoblastic Leukemia. N Engl J Med 2018 Feb 1; 378(5): 449-459. [DOI]
3. Fallah Bafekr Lialestani B, Eshagh Hosseini SK, Mohammadi S, et al. Assessment of Five- Year Survival of Children with Acute Lymphatic Leukemia and Its Related Factors in Qom Province, (Iran). Qom Univ Med Sci J 2019; 13(1): 30-7. (Persian) [DOI]
4. Nikpour S, Rahimian S, Shokrabi S, et al. Related factors of acute leukemia in children and the role of breast feeding. Iranian Journal of Endocrinology and Metabolism 2012;14(1): 63-67. [Article]
5. Fani Pakdel A, Elyasi S, Kooshiar MM, et al. Identification and analysis of adverse drug reactions associated with colorectal and gastric cancer chemotherapy in hospitalized patients. medical journal of Mashhad University of Medical Sciences 2018; 61(2): 921-30. [DOI]
6. Mohamadi S, Jalali F, Rekabpour SJ. Risk Factors of Breast Cancer in Women of Bushehr City: A Case-Control Study. Iran South Med J; 2023; 25(6): 505-518. [Article]
7. Hovi L, Era P, Rautonen J, et al. Impaired muscle strength in female adolescents and young adults surviving leukemia in childhood. Cancer 1993; 72(1): 276- 81. [DOI]
8. Neglia JP, Friedman DL, Yasui Y, et al. Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study. J Natl Cancer Inst 2001; 93(8): 618-29. [DOI]
9. Li J, Luo H, Chen Y , et al. Comparison of the Predictive Value of Inflammatory Biomarkers for the Risk of Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke. Clin Interv Aging 2023; 18: 1477-1490. [DOI]
10. Borden LS Jr, Clark PE, Lovato J, et al. Vinorelbine, doxorubicin, and prednisone in androgen-independent prostate cancer. Cancer 2006; 107(5): 1093-100. [DOI]
11. Wu AH, Perryman MB. Clinical applications of muscle enzymes and proteins. Curr Opin Rheumatol 1992; 4(6): 815-20. [DOI]
12. Zahran AM, Riad KF, Elsayh KI, et al. Role of pretreatment inflammatory indicators in pediatric acute leukemias; where do we stand? A prospective cohort study. Cancer Biomark 2020; 29(4): 553-564. [DOI]
13. Li X, Jiang F, Ge Z, et al. Fructose-Bisphosphate Aldolase A Regulates Hypoxic Adaptation in Hepatocellular Carcinoma and Involved with Tumor Malignancy. Dig Dis Sci 2019; 64(11): 3215-3227. [DOI]
14. Kiely PD, Bruckner FE, Nisbet JA, et al. Serum skeletal troponin I in inflammatory muscle disease: relation to creatine kinase, CKMB and cardiac troponin I. Ann Rheum Dis 2000; 59(9): 750-1. [DOI]
15. Ahmed MB, Shehata HH, Moussa M, et al. Prognostic significance of survivin and tumor necrosis factor-alpha in adult acute lymphoblastic leukemia. Clin Biochem 2012; 45(1-2): 112-6. [DOI]
16. Monici MC, Aguennouz M, Mazzeo A , et al. Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology 2003 Mar 25; 60(6): 993-7. [DOI]
17. Vyas D, Laput G, Vyas AK. Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis. Onco Targets Ther 2014; 12: 7: 1015-23. [DOI]
18. Soontrapa P, Shahar S, Eauchai L , et al. Disease spectrum of myopathies with elevated aldolase and normal creatine kinase. Eur J Neurol 2024; 31(2): e16117. [DOI]
19. Mobarak-Abadi A, Moshfeghi K, Almasi-Hashiani A. Influencing Factors in childhood leukemia in patients who referred to Amir Kabir Hospital in Arak. Journal of North Khorasan University of Medical Sciences 2015; 6(4): 905-12. [DOI]
20. Morel S, L éveill é P, Samoilenko M , et al. Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia. Sci Rep 2020; 10(1): 21507. [DOI]
21. Rafieemehr H, Calhor F, Esfahani H , et al. Risk of Acute Lymphoblastic Leukemia: Results of a Case-Control Study. Asian Pac J Cancer Prev 2019; 20(8): 2477-2483. [DOI]
22. Nozaki K, Pestronk A. High aldolase with normal creatine kinase in serum predicts a myopathy with perimysial pathology. J Neurol Neurosurg Psychiatry 2009; 80(8): 904-8. [DOI]
23. Tol édano C, Gain M, Kettaneh A , et al. Aldolase predicts subsequent myopathy occurrence in systemic sclerosis. Arthritis Res Ther 2012; 14(3): R152. [DOI]
24. Cheung YT, To KK, Hua R , et al. Association of markers of inflammation on attention and neurobehavioral outcomes in survivors of childhood acute lymphoblastic leukemia. Front Oncol 2023; 13: 1117096. [DOI]
25. Richard AE, Hodges EK, Heinrich KP. Visual attention and math performance in survivors of childhood acute lymphoblastic leukemia. Arch Clin Neuropsychol 2018; 33(8): 1015–23. [DOI]
26. Omran MM, Ibrahim AB, Abdelfattah R , et al. Imatinib pharmacokinetics and creatine kinase levels in chronic myeloid leukemia patients: implications for therapeutic response and monitoring. Eur J Clin Pharmacol 2024; 80(7): 1061-1068. [DOI]
27. Jamshidi A, Esmaielzadeh A, Kousha Ali. 8-year study of hematologic malignancies. J Zanjan Univ Med Sci 2004; 12(46): 47-53. (Persian) [Article]
28. Toro-Salazar OH, Lee JH, Zellars KN , et al. Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines. Cardiooncology 2018; 4: 4. [DOI]
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