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:: Volume 14, Issue 3 (Iranian South Medical Journal 2011) ::
Iran South Med J 2011, 14(3): 173-178 Back to browse issues page
Comparison the prevalence of isolated Hepatitis B core antibody among injection drug users with blood donors in central province in IRAN
Masoomeh Soufian, Fatemeh Sadat Mahdaviani, Nabiollah Izadi, Ali Mousavinejad, Hossein Sarmadian, Nader Zarrinfar, Manizheh Kahbazi, Ali Asghar Farazi 1
1- , farazialiasghar@yahoo.com
Abstract:   (12133 Views)

Background: In healthy blood donors, 2%–5% have isolated anti-HBc. Prevalence of hepatitis B, C and co- infection (HBV +HCV) among injection drug user is high. Hepatitis C suppress of HB SAg and may be hepatitis B presented only with isolated anti HBC. This study determined of prevalence of isolated anti HBC among injection drug users and compare with blood donors in Arak city. Methods: A total 684 subjects (531voluntary blood donors and 153 injection drug users) in Arak, Iran were included in this study. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), anti-HBc, and hepatitis C antibody (anti-HCV) were tested in all subjects. Results: A total of 531 voluntary blood donors living in the city of Arak, in the Central Province of Iran, with a mean age of 36 ± 10.18 years (range 16–60 years) were enrolled in the study. Ninety-three percent of patients were male and 7% were female. Of the 531 cases, 11 subjects (2.1%) had isolated anti-HBc. A total of 153 injection drug users of Arak, in the Central Province of Iran, with a mean age of 30.66 ± 5.92 years (range 20-50 years) were enrolled in the study. All of them were male. Of the 153 cases, 12 subjects (7.84%) had isolated anti-HBc. All of 12 cases were HCV positive. Conclusion: Prevalence of isolated anti-HBc among injection drug users was 3. 73 fold in comparison with blood donors. For diagnosis of hepatitis B in this group test for anti-HBc will be done. Evaluation of occult hepatitis B in subject with isolated anti-HBc by exact method such as real time PCR is necessary.

Keywords: isolated anti-HBc, injection drug users, prevalence, hepatitis
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Type of Study: Original | Subject: General
Received: 2011/04/21 | Accepted: 2011/05/1 | Published: 2011/08/2
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Soufian M, Mahdaviani F S, Izadi N, Mousavinejad A, Sarmadian H, Zarrinfar N, et al . Comparison the prevalence of isolated Hepatitis B core antibody among injection drug users with blood donors in central province in IRAN. Iran South Med J. 2011; 14 (3) :173-178
URL: http://ismj.bpums.ac.ir/article-1-271-en.html


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Volume 14, Issue 3 (Iranian South Medical Journal 2011) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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