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:: Volume 9, Issue 2 (Iranian south medical of journals 2007) ::
Iran South Med J 2007, 9(2): 114-122 Back to browse issues page
Effect of esophageal distention on basal and stimulated gastric acid secretion in rats
Mohammad Kazem Gharib Nasery, Seyed Ali Mard 1, Mohammad Badvi
1- , a_mard2003@yahoo.com
Abstract:   (15566 Views)
Background: It is well established that the esophageal distention leads to gastric relaxation, partly by vago-vagal reflex but till now, the effect of esophageal distention on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of esophageal distention (ED) on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240g) were deprived of food but not water for 24 hrs before the experiments. Under urethane anesthesia (1.2 g/kg, i.p.), animals underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distention and gastric washout and the esophagus was cannulated with a distensible balloon orally to distend esophagus (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distention, carbachol (4 µg/kg, i.p.) or histamine (5 mg/kg, s.c.). Effects of vagotomy, L-NAME (10 mg/kg, i.v.), L-arginine (500 mg/kg, i.p.) and hexamethonium were also investigated. Results: Esophageal distention reduces basal and gastric distention, carbachol and histamine stimulated acid secretion (P<0.05, P<0.0001, P<0.01 and P<0.02, respectively). Vagotomy reduced the inhibitory effect of the esophagus distention on gastric distention-induced acid secretion (P<0.05). Conclusion: These results indicate that vagus nerve involves in the inhibitory effect of the esophageal distention on the basal and stimulated gastric acid secretion. Nitric oxide (NO) may also be involved.
Keywords: esophageal distention, gastric acid secretion, nitric oxide, carbachol, histamine, vagotomy
Full-Text [PDF 343 kb]   (1805 Downloads)    
Type of Study: Original | Subject: General
Received: 2006/08/3 | Accepted: 2007/03/1 | Published: 2009/01/13
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Gharib Nasery M K, Mard S A, Badvi M. Effect of esophageal distention on basal and stimulated gastric acid secretion in rats. Iran South Med J. 2007; 9 (2) :114-122
URL: http://ismj.bpums.ac.ir/article-1-28-en.html


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Volume 9, Issue 2 (Iranian south medical of journals 2007) Back to browse issues page
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