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:: Volume 17, Issue 3 (Iranian South Medical journal 2014) ::
Iran South Med J 2014, 17(3): 318-325 Back to browse issues page
Comparison between Efficacy of Ciprofioxacin -Doxycycline with Rifampin – Doxycycline Regimens inrelapse of Brucellosis
Hossein Sarmadian1, Farshideh Didgar2, Reza Ghasemikah3
1- Department of Infectious Disease, School of Medicine, Arak University of Medical Sciences, Arak, IRAN
Tuberculosis and pediatric infectious research center, Arak University of Medical Sciences, Arak, IRAN
2- Department of Infectious Disease, School of Medicine, Arak University of Medical Sciences, Arak, IRAN
Tuberculosis and pediatric infectious research center, Arak University of Medical Sciences, Arak, IRAN , fdidgar@yahoo.com
3- Tuberculosis and pediatric infectious research center, Arak University of Medical Sciences, Arak, IRAN
Department of Parasitology & Mycology, School of Medicine, Arak University of medical sciences, Arak, IRAN.
Abstract:   (7121 Views)

Background: Brucellosis is one of the endemic diseases in Iran that has a worldwide spread and is associated with chronic disabilities in humans. Combination therapy of Brucellosis leads to recovery of symptoms, shortening of the symptomatic intervals, and decrease in the rate of relapse and drug resistance. Considering the use of rifampin in the treatment of tuberculosis, and the necessity for an alternative treatment in regions endemic for both tuberculosis and brucellosis, the aim ofthis study was to compare the efficiency of the regimen of rifampin-Doxycycline with ciprofloxacin-Doxycycline in relapse of brucellosis. Materials and methods: This randomized controlled trial was performed on 90 patients, older than 17 years old, affected with brucellosis, which were referred to the Infectious Disease Clinics at ArakUniversity of medical sciences between the years 1384-1387. The patients were randomly divided into two groups: the DR groups, receiving 100 mg of Doxycycline twice a day and 300 mg of rifampin Bid daily for eight weeks and the CD group, receiving 100 mg of Doxycycline plus 500 mg of ciprofloxacin twice a day for eight weeks. The patients were analyzed for the relief of symptoms, drug side effects, and laboratory findings during the treatment. Results:In this study, the rate of relapse in both groups were similar. The relapse was seen in 4.5% and 3.2% of the patients for the DR and CD groups, respectively (P=0.168). The drug side effects were slight in both of groups, with no significant difference, and did not lead to discontinuation of the therapy. Conclusion: According to the same rate of relapse in both CD and DR regimens in the treatment of brucellosis and considering the usage of rifampin in regions with high prevalence of tuberclusis, the CD regimen is recommended as an appropriate one.

Keywords: Doxycycline, Rifampin, Ciprofloxacin, Relapse of brucellosis
Full-Text [PDF 775 kb]   (2271 Downloads)    
Type of Study: Original | Subject: General
Received: 2012/08/1 | Accepted: 2012/10/13 | Published: 2014/06/14
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Sarmadian H, Didgar F, Ghasemikah R. Comparison between Efficacy of Ciprofioxacin -Doxycycline with Rifampin – Doxycycline Regimens inrelapse of Brucellosis. Iran South Med J. 2014; 17 (3) :318-325
URL: http://ismj.bpums.ac.ir/article-1-544-en.html


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Volume 17, Issue 3 (Iranian South Medical journal 2014) Back to browse issues page
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