[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 8, Issue 2 (Iranian south medical of journals 2006) ::
Iran South Med J 2006, 8(2): 110-118 Back to browse issues page
Effects of Ciprofloxacin on rat Sertoli cells
Arash Khaki Mr 1, Parviz Bazzi Mr, Marefat Ghafari Novin Ms
1- , dr.khaki@iaut.ac.ir
Abstract:   (15531 Views)
Background: Ciprofloxacin is a synthetic antibacterial agent from the fluoroquinolones family with a very broad spectrum against microbial pathogens, especially Gram-negative infectious diseases, which has been approved in more than 100 countries world-wide. This study was planed to identify the histopathological effects of ciprofloxacin on rat Sertoli cells. Methods: Twenty male Wistar rats were selected and randomly divided into two groups control (n=10) and experimental (n=10). The experimental group received 12.5 mg/kg oral ciprofloxacin daily for sixty days. On sixtieth day the testis tissues in both groups were removed and weighted, then prepared for light microscopy and electron microscopy studies. Results: There was a marked decrease in testicular weight, marked accumulation and atrophy of seminiferous tubules of Sertoli cells in experimental group as compared with control group (P<0.05). Conclusion: Ciprofloxacin can induce marked histological alteration in testicular tissue of rat, therefore these histological effects and possibility of producing infertility should be investigated in human subjects.
Keywords: ciprofloxacin, Sertoli cells, testis, rat
Full-Text [PDF 4176 kb]   (3416 Downloads)    
Type of Study: Original | Subject: General
Received: 2005/11/11 | Accepted: 2006/02/20 | Published: 2009/01/15
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khaki A, Bazzi P, Ghafari Novin M. Effects of Ciprofloxacin on rat Sertoli cells . Iran South Med J. 2006; 8 (2) :110-118
URL: http://ismj.bpums.ac.ir/article-1-65-en.html

Volume 8, Issue 2 (Iranian south medical of journals 2006) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4312