Volume 26, Issue 5 (Iranian South Medical Journal 2024)
Iran South Med J 2024, 26(5): 324-340 |
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1- Children Growth Research Center, Research Institute for Prevention of Non- Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
2- Children Growth Research Center, Research Institute for Prevention of Non- Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran ,banafsheh.arad@gmail.com
2- Children Growth Research Center, Research Institute for Prevention of Non- Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran ,
Abstract: (1325 Views)
Background: In the process of treating children with primary monosymptomatic nocturnal enuresis (PMNE), the relapse of PMNE after stopping the medicine causes the child to take the medicine for a prolonged time. The purpose of this study is to compare the rate of disease relapse in two groups of PMNE treatment with a combination of desmopressin + tolterodine and desmopressin alone.
Materials and Methods: One hundred twenty-three patients of both genders, suffering from nocturnal enuresis, 5-16 years old, were examined in a randomized, single-blind, single-center clinical trial. The first group was given one puff of desmopressin nasal spray and the second group was given one puff of desmopressin nasal spray + 1 mg tolterodine one hour before going to sleep. Data were analyzed using SPSS 21 software and Chi-Square and student t-test (P<0.05).
Results: The positive response of the patients to the treatment in the desmopressin treatment group was 100% and the relapse rate after stopping the treatment was 47.1%. In the desmopressin + tolterodine group, 96.4% responded positively to the treatment, and relapse after stopping the treatment was observed in 34.5% of them. There was no significant difference between the two groups in terms of response rate to treatment (P=0.11) and relapse after stopping the treatment (P=0.16).
Conclusion: Treatment with desmopressin and desmopressin + tolterodine was effective in reducing PMNE relapse after the initial treatment process in children. Considering that there was no statistically significant difference between the desmopressin and desmopressin + tolterodine treatment groups, there is no need to add tolterodine to the treatment regimen of nocturnal enuresis.
Materials and Methods: One hundred twenty-three patients of both genders, suffering from nocturnal enuresis, 5-16 years old, were examined in a randomized, single-blind, single-center clinical trial. The first group was given one puff of desmopressin nasal spray and the second group was given one puff of desmopressin nasal spray + 1 mg tolterodine one hour before going to sleep. Data were analyzed using SPSS 21 software and Chi-Square and student t-test (P<0.05).
Results: The positive response of the patients to the treatment in the desmopressin treatment group was 100% and the relapse rate after stopping the treatment was 47.1%. In the desmopressin + tolterodine group, 96.4% responded positively to the treatment, and relapse after stopping the treatment was observed in 34.5% of them. There was no significant difference between the two groups in terms of response rate to treatment (P=0.11) and relapse after stopping the treatment (P=0.16).
Conclusion: Treatment with desmopressin and desmopressin + tolterodine was effective in reducing PMNE relapse after the initial treatment process in children. Considering that there was no statistically significant difference between the desmopressin and desmopressin + tolterodine treatment groups, there is no need to add tolterodine to the treatment regimen of nocturnal enuresis.
Keywords: Nocturnal enuresis relapse, desmopressin, tolterodine, primary monosymptomatic nocturnal enuresis
Type of Study: Original |
Subject:
General
Received: 2023/09/17 | Accepted: 2024/04/9 | Published: 2024/05/5
Received: 2023/09/17 | Accepted: 2024/04/9 | Published: 2024/05/5
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