Volume 22, Issue 3 (Iranian South Medical Journal 2019)
Iran South Med J 2019, 22(3): 141-149 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Baneshi A R, Nowroozi Asl A, Darya G, Hashemi F, Musavi S M. Effect of Hydroalcoholic Extract of Glaucium flavum Crantz on Thyroid Hormones in Alloxan Diabetic Rats. Iran South Med J 2019; 22 (3) :141-149
URL: http://ismj.bpums.ac.ir/article-1-1093-en.html
URL: http://ismj.bpums.ac.ir/article-1-1093-en.html
Ali Reza Baneshi1 
, Ardovan Nowroozi Asl1 , GholamHosseain Darya * 2, Farid Hashemi3 , Seyedeh Maryam Musavi4
, Ardovan Nowroozi Asl1 , GholamHosseain Darya * 2, Farid Hashemi3 , Seyedeh Maryam Musavi4
1- Department of Clinical Sciences, School of Veterinary Medicine, Kazerun branch, Islamic Azad University, Kazerun, Iran
2- Young Researcher and Elites Club, Kazerun branch, Islamic Azad University, Kazerun, Iran ,ghdarya88@gmail.com
3- Young Researcher and Elites Club, Kazerun branch, Islamic Azad University, Kazerun, Iran
4- Department of Clinical Sciences, School of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
2- Young Researcher and Elites Club, Kazerun branch, Islamic Azad University, Kazerun, Iran ,
3- Young Researcher and Elites Club, Kazerun branch, Islamic Azad University, Kazerun, Iran
4- Department of Clinical Sciences, School of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
Abstract: (4235 Views)
Background: Thyroid dysfunction is one of the controversial complications of diabetes. Given the hypoglycemic properties of Yellow Horne Poppy (YHP), this study was conducted to evaluate the effect of oral administration of aqua-ethanolic extract of YHP and glibenclamide on serum level of T3 and T4 hormones in alloxan diabetic rats compared to healthy rats.
Materials and Methods: In this experimental study, 56 male Wistar rats were randomly divided into seven groups of 8, including healthy control, healthy treated with 250 and 500 mg/kg of YHP extract, diabetic control, diabetic treated with 250 and 500mg/kg of YPH extract and diabetic treated with 5μg/kg of glibenclamide. Diabetes was induced by intraperitoneal injection of a single dose of alloxan. After 30 days of treatment, blood samples were collected and the concentration of thyroid hormones T3 and T4 were measured. Finally, the data were analyzed using one-way ANOVA.
Results: The serum concentrations of thyroid hormones were significantly lower in the diabetic control group than those in the control group (P<0.001). The mean concentration of T3 was significantly higher in the diabetic+250 extract than that in the diabetic control group (P<0.001). Also, the mean concentration of T4 was significantly higher in the diabetic+250 extract than that in the diabetic+drug group (P=0.04).
Conclusion: YPH extract can effectively improve T3 and T4 serum levels in diabetic rats. Further studies are required to determine the active ingredient responsible for this therapeutic effect, such as Glaucin.
Materials and Methods: In this experimental study, 56 male Wistar rats were randomly divided into seven groups of 8, including healthy control, healthy treated with 250 and 500 mg/kg of YHP extract, diabetic control, diabetic treated with 250 and 500mg/kg of YPH extract and diabetic treated with 5μg/kg of glibenclamide. Diabetes was induced by intraperitoneal injection of a single dose of alloxan. After 30 days of treatment, blood samples were collected and the concentration of thyroid hormones T3 and T4 were measured. Finally, the data were analyzed using one-way ANOVA.
Results: The serum concentrations of thyroid hormones were significantly lower in the diabetic control group than those in the control group (P<0.001). The mean concentration of T3 was significantly higher in the diabetic+250 extract than that in the diabetic control group (P<0.001). Also, the mean concentration of T4 was significantly higher in the diabetic+250 extract than that in the diabetic+drug group (P=0.04).
Conclusion: YPH extract can effectively improve T3 and T4 serum levels in diabetic rats. Further studies are required to determine the active ingredient responsible for this therapeutic effect, such as Glaucin.
Type of Study: Original |
Subject:
Endocrine System
Received: 2019/03/9 | Accepted: 2019/05/20 | Published: 2019/07/1
Received: 2019/03/9 | Accepted: 2019/05/20 | Published: 2019/07/1
References
1. Sugahara M, Tanaka T, Inagi R, et al. Diabetic Kidney Disease. In: Yamagishi S, editors. Diabetes and Aging-related Complications. Springer, 2017, 1-17. [DOI:10.1007/978-981-10-4376-5_1]
2. Kumar V, Abbas A, Aster J. Robbins Basic Pathology. 9th ed. Philadelphia: Saunders, 2012, 343-5. [Article]
3. Hall JE. 2015. Guyton and Hall Textbook of Medical Physiology: Elsevier Health Sciences. 2015, 862. [Article]
4. Xu M, Bi Y, Cui B, et al. The New Perspectives on Genetic Studies of Type 2 Diabetes and Tthyroid Diseases. Current Genom 2013; 14(1): 33-48. [DOI:10.2174/138920213804999138]
5. Ambadiari V, Mitrou P, Maratou E, et al. Thyroid Hormones are Positively Associated with Iinsulin Resistance Early in the Development of Type 2 Diabetes. Endocrine 2011; 39(1): 28-32. [DOI:10.1007/s12020-010-9408-3]
6. Dehghani F, Kalantar Hormozi M, Nabipour I, et al. Effects of Short Term Resveratrol Supplementation on Thyroid Function in Patients with Type 2 Diabetes. Iran South Med J 2018; 21(5): 374-382. (Persian) [Article]
7. Martel J, Ojcius DM, Chang CJ, et al. Anti-Obesogenic and Antidiabetic Effects of Plants and Mushrooms. Nat Rev Endocrinol 2016; 13: 149. [DOI:10.1038/nrendo.2016.142]
8. Krysiak R, Gilowska M, Szkróbka W, et al. The Effect of Metformin on the HypothalamicPituitary-Thyroid Axis in Patients with Type 2 Diabetes and Amiodarone-Iinduced Hypothyroidism. Pharmaco Rep 2016; 68(2): 490-4. [DOI:10.1016/j.pharep.2015.11.010]
9. Shafiee A, Lalezari I, Lajevardi S, et al. Alkaloids of Glaucium Flavum Grantz, Populations Isfahan and Kazerun. J Pharm Sci 1977; 66(6): 873-4. [DOI:10.1002/jps.2600660636]
10. Gran A, Sharifnia F. Micro-Macro Morphological Studies of the Genus Glaucium (Papaveraceae) in Iran. Iran J Bot 2008; 14(1): 23-38. [Article]
11. Bogdanov MG, Svinyarov I, Keremedchieva R, et al. Ionic Liquid-Supported Solid-Liquid Extraction of Bioactive Alkaloids. I. New HPLC Method for Quantitative Determination of Glaucine in Glaucium Flavum Cr(Papaveraceae). Sep Purif Technol 2012; 97: 221-7. [DOI:10.1016/j.seppur.2012.02.001]
12. Cortijo J, Villagrasa V, Pons R, et al. Bronchodilator and Anti‐Inflammatory Activities of Glaucine: In Vitro Studies in Human Airway Smooth Muscle and Polymorphonuclear Leukocytes. Br J Pharmacol 1999; 127(7): 1641-51. [DOI:10.1038/sj.bjp.0702702]
13. Spasova M, Philipov S, Nikolaeva-Glomb L, et al. Cinnamoyl-and Hydroxycinnamoyl Amides of Glaucine and Their Antioxidative and Antiviral Activities. Bioorg Med Chem 2008; 16(15): 7457-61. [DOI:10.1016/j.bmc.2008.06.010]
14. Dargan P, Button J, Hawkins L, et al. Detection of the Pharmaceutical Agent Glaucine as a Recreational Drug. Eur J Clin Pharmacol 2008; 64(5): 553-4. [DOI:10.1007/s00228-007-0451-9]
15. Raafat K, El-Lakany A. Phytochemical and Antinociceptive Investigations of Anemone Coronaria Active Part Ameliorating Diabetic Neuropathy Pain. Planta Med Int Open 2018; 5(1): 5-13. [DOI:10.1055/s-0044-100148]
16. Hamamcioglu B, Kocanci FG, Aslim B. Phytochemical Screening and Evaluation of Neuroprotective, Anti-Mutagenic and AntiGenotoxic Effects of Turkish Endemic Glaucium Acutidentatum. S Afr J Bot 2018; 117: 232-9. [DOI:10.1016/j.sajb.2018.05.027]
17. Lenzen S. The Mechanisms of Alloxan-and Streptozotocin-induced Diabetes. Diabetologia 2008; 51(2): 216-26. [DOI:10.1007/s00125-007-0886-7]
18. Darya GH, Nowroozi-Asl A, Khoshvaghti A, et al. Effect of Hydro-Alcoholic Extract of Yellow Horned Poppy (Glaucium Flavum) on Serum Concentration of Glucose and Lipid Profile and Weight Changes in Alloxan Induced Diabetic Rats. Sci J Kurdistan Univ Med Sci 2019; 24(1): 45-55. [Article]
19. Tiwari BK, Pandey KB, Abidi A, et al. Markers of Oxidative Stress During Diabetes Mellitus. J Biomark 2013; 15-23. [DOI:10.1155/2013/378790]
20. Santos MC, Louzada RA, Souza EC, et al. Diabetes Mellitus Increases Reactive Oxygen Species Production in the Thyroid of Male Rats. Endocrinology 2013; 154(3): 1361-72. [DOI:10.1210/en.2012-1930]
21. Beidokhti MN, Rasoavaivo P, Staerk D, et al. Investigation of Medicinal Plants from Madagascar Against DPP-IV Linked to Type 2 Diabetes. S Afr J Bot 2018; 115: 113-9. [DOI:10.1016/j.sajb.2018.01.018]
22. Panda S. The Effect of Anethum Graveolens L.(Dill) on Corticosteroid Induced Diabetes Mellitus: Involvement of Thyroid Hormones. Phytother Res 2008; 22(12): 1695-7. [DOI:10.1002/ptr.2553]
23. Patel S, Santani D. Role of NF-κB in the Pathogenesis of Diabetes and Its Associated Complications. Pharmacol Rep 2009; 61(4): 595-603. [DOI:10.1016/S1734-1140(09)70111-2]
24. Wang C, Dai X, Zhang D, et al. Jinlida Granules Improve Dysfunction of Hypothalamic-Pituitary-Thyroid Axis in Diabetic Rats Induced by STZ. Biomed Res Int 2018; 2018: 5-14. [DOI:10.1155/2018/4764030]
25. Wajner SM, Goemann IM, Bueno AL, et al. IL-6 Promotes Nonthyroidal Illness Syndrome by Blocking Thyroxine Activation While Promoting Thyroid Hormone Inactivation in Human Cells. J Clin Invest 2011; 121(5): 1834-45. [DOI:10.1172/JCI44678]
26. Bogdanov MG, Keremedchieva R, Svinyarov I. Ionic Liquid-Supported Solid-Liquid Extraction of Bioactive Alkaloids. III. Ionic Liquid Regeneration and Glaucine Recovery from Ionic Liquid-Aqueous Crude Extract of Glaucium Flavum Cr.(Papaveraceae). Sep Purif Technol 2015; 155: 13-9 [DOI:10.1016/j.seppur.2015.02.003]
27. Kang H, Jang SW, Pak JH, et al. Glaucine Inhibits Breast Cancer Cell Migration and Invasion by Inhibiting MMP-9 Gene Expression Through the Suppression of NF-κB Activation. Mol Cell Biochem 2015; 403(1): 85-94 [DOI:10.1007/s11010-015-2339-9]
28. Gyurkovska V, Philipov S, Kostova N, et al. Acetylated Derivative of Glaucine Inhibits Joint Inflammation in Collagenase-Induced Arthritis. Immunopharmacol Immunotoxicol 2015; 37(1): 56-62. [DOI:10.3109/08923973.2014.972414]
Send email to the article author
| Rights and Permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
