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:: Volume 23, Issue 3 (Iranian South Medical Journal 2020) ::
Iran South Med J 2020, 23(3): 222-235 Back to browse issues page
Correlation of CCL18 with Levels of Adi-pokines in the Sera of Patients with Myocardial Infarction in a 6-Month Period: Case Series
Atefeh GamarTalepoor1 , Ehsan Dowlatshahi1, Mehrnoush Doroudchi 2
1- Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , mdoroud@sums.ac.ir
Abstract:   (384 Views)
Background: Myocardial Infarction (MI) is accompanied by inflammation and production of soluble inflammatory factors. The aim of this study was to investigate the correlation of CCL18 and CCL5 levels with those of resistin, adipsin, adiponectin and leptin adipokines in the sera of patients after MI.
Materials and Methods: The correlations between levels of chemokines and adipokines were investigated in 36 patients in a 6-month follow-up after MI. For each patient, the measurements were done in 3 time points T0 (first 12 hrs), T5 (fifth day of admission) and T180 (after 6 months). The clinical and demographical criteria of patients at the time of admission were also recorded.
Results: The serum levels of CCL18 at T0 were significantly correlated with resistin levels at T180. Therefore, higher CCL18 levels at T0 were associated with higher resistin levels at T180 (r=0.413, P=0.017). Moreover, serum levels of CCL18 at T180 were significantly correlated with adipsin levels at T5. Therefore, higher adipsin levels at T5 were associated with higher CCL18 levels at T180 (r=0.213, P=0.001).
Multivariate logistic regression showed that the left ventricular ejection fraction at T0 correlated with the covariant effect of adipsin T5 and CCL18 at T180 (P=0.029).
Conclusion: This study showed the correlation between CCL18 and resistin levels and the effect of CCL18 on the long term production of resistin in the body. With the notion that worse prognosis is associated with higher long-term CCL18; it is possible to take advantage of the correlation between adipsin on day 5 and the increase in CCL18 as prognostic biomarkers on the first days after MI.
Keywords: Chemokine, Adipokine, Myocardial infarction, Resistin, Adipsin
Full-Text [PDF 1246 kb]   (97 Downloads)    
Type of Study: Original | Subject: Physiology
Received: 2019/12/7 | Accepted: 2020/04/12 | Published: 2020/07/27
1. Vajen T, Koenen RR, Werner I, et al. Blocking CCL5-CXCL4 Heteromerization Preserves Heart Function After Myocardial Infarction By Attenuating Leukocyte Recruitment And Netosis. Sci Rep 2018; 8(1): 10647.
2. Virani SS, Nambi V, Hoogeveen R, et al. Relationship Between Circulating Levels Of RANTES (Regulated On Activation, Normal T-Cell Expressed, And Secreted) And Carotid Plaque Characteristics: The Atherosclerosis Risk In Communities (ARIC) Carotid MRI Study. Eur Heart J 2011; 32(4): 459-68.
3. Aukrust P, Halvorsen B, Yndestad A, et al. Chemokines And Cardiovascular Risk. Arterioscler Thromb Vasc Biol 2008; 28(11): 1909-19.
4. De Sutter J, Struyf S, Van De Veire NR, et al. Cardiovascular Determinants And Prognostic Significance Of CC Chemokine Ligand-18 (CCL18/PARC) In Patients With Stable Coronary Artery Disease. J Mol Cell Cardiol 2010; 49(5): 894-6.
5. Cabia B, Andrade S, Carreira MC, et al. A Role For Novel Adipose Tissue-Secreted Factors In Obesity-Related Carcinogenesis. Obes Rev 2016; 17(4): 361-76.
6. Wajchenberg BL. Subcutaneous And Visceral Adipose Tissue: Their Relation To The Metabolic Syndrome. Endocr Rev 2000; 21(6): 697-738.
7. Gesta S, Tseng YH, Kahn CR. Developmental Origin Of Fat: Tracking Obesity To Its Source. Cell 2007; 131(2): 242-56.
8. Wozniak SE, Gee LL, Wachtel MS, et al. Adipose Tissue: The New Endocrine Organ? A Review Article. Dig Dis Sci 2009; 54(9): 1847-56.
9. Scheja L, Heeren J. The Endocrine Function Of Adipose Tissues In Health And Cardiometabolic Disease. Nat Rev Endocrinol 2019; 15(9): 507-24.
10. Booth A, Magnuson A, Fouts J, et al. Adipose Tissue: An Endocrine Organ Playing A Role In Metabolic Regulation. Horm Mol Biol Clin Investig 2016; 26(1): 25-42.
11. Balistreri CR, Caruso C, Candore G. The Role Of Adipose Tissue And Adipokines In Obesity-Related Inflammatory Diseases. Mediators Inflamm 2010; 2010: 802078.
12. Juge-Aubry CE, Henrichot E, Meier CA. Adipose Tissue: A Regulator Of Inflammation. Best Pract Res Clin Endocrinol Metab 2005; 19(4): 547-66.
13. Pineiro R, Iglesias MJ, Gallego R, et al. Adiponectin Is Synthesized And Secreted By Human And Murine Cardiomyocytes. FEBS Lett 2005; 579(23): 5163-9.
14. Wang Y, Lau WB, Gao E, et al. Cardiomyocyte-Derived Adiponectin Is Biologically Active In Protecting Against Myocardial Ischemia-Reperfusion Injury. Am J Physiol Endocrinol Metab 2010; 298(3): e663-70.
15. Yamaguchi T, Kitamori K, Ichihara G, et al. Serial Changes In Adipocytokines And Cardiac Function In A Rat Model Of The Metabolic Syndrome. Clin Exp Pharmacol Physiol 2013; 40(7): 443-8.
16. Michalski B, Szymczyk E, Peczek L, et al. The Role Of Selected Adipokines And Ghrelin In The Prognosis After Myocardial Infarction In A 12-Month Follow-Up In The Presence Of Metabolic Syndrome. Arch Med Sci 2017; 13(4): 785-94.
17. Mancuso P. The Role Of Adipokines In Chronic Inflammation. Immunotargets Ther 2016; 5: 47-56.
18. Sull JW, Kim HJ, Yun JE, et al. Serum Adiponectin Is Associated With Smoking Status In Healthy Korean Men. Endocr J 2009; 56(1): 73-8.
19. Mancuso P, Huffnagle GB, Olszewski MA, et al. Leptin Corrects Host Defense Defects After Acute Starvation In Murine Pneumococcal Pneumonia. Am J Respir Crit Care Med 2006; 173(2): 212-8.
20. Kumada M, Kihara S, Sumitsuji S, et al. Association Of Hypoadiponectinemia With Coronary Artery Disease In Men. Arterioscler Thromb Vasc Biol 2003; 23(1): 85-9.
21. Izadi M, Zarifian A, Eghdami A, et al. Relationship between cardiovascular risk factors and blood adiponectin in diabetic males. Iran South Med J 2012; 15(2): 101-7.
22. Lau WB, Ohashi K, Wang Y, et al. Role Of Adipokines In Cardiovascular Disease. Circ J 2017; 81(7): 920-8.
23. Ntaios G, Gatselis NK, Makaritsis K, et al. Adipokines As Mediators Of Endothelial Function And Atherosclerosis. Atherosclerosis 2013; 227(2): 216-21.
24. Mocan Hognogi LD, Goidescu CM, Farcas AD. Usefulness Of The Adipokines As Biomarkers Of Ischemic Cardiac Dysfunction. Dis Markers 2018; 2018: 3406028.
25. Lai B, Wang J, Fagenson A, et al. Twenty Novel Disease Group-Specific And 12 New Shared Macrophage Pathways In Eight Groups Of 34 Diseases Including 24 Inflammatory Organ Diseases And 10 Types Of Tumors. Front Immunol 2019; 10: 2612.
26. Lubos E, Messow CM, Schnabel R, et al. Resistin, Acute Coronary Syndrome And Prognosis Results From The Atherogene Study. Atherosclerosis 2007; 193(1): 121-8.
27. Takeishi Y, Niizeki T, Arimoto T, et al. Serum Resistin Is Associated With High Risk In Patients With Congestive Heart Failure--A Novel Link Between Metabolic Signals And Heart Failure. Circ J 2007; 71(4): 460-4.
28. Grzywocz P, Mizia-Stec K, Wybraniec M, et al. Adipokines And Endothelial Dysfunction In Acute Myocardial Infarction And The Risk Of Recurrent Cardiovascular Events. J Cardiovasc Med (Hagerstown) 2015; 16(1): 37-44.
29. Sajedi Khanian M, Abdi Ardekani A, Khosropanah S, et al. Correlation Of Early And Late Ejection Fractions With CCL5 And CCL18 Levels In Acute Anterior Myocardial Infarction. Iran J Immunol 2016; 13(2): 100-13.
30. Jamaluddin MS, Weakley SM, Yao Q, et al. Resistin: Functional Roles And Therapeutic Considerations For Cardiovascular Disease. Br J Pharmacol 2012; 165(3): 622-32.
31. Savage DB, Sewter CP, Klenk ES, et al. Resistin / Fizz3 Expression In Relation To Obesity And Peroxisome Proliferator-Activated Receptor-Gamma Action In Humans. Diabetes 2001; 50(10): 2199-202.
32. Kuzmicki M, Telejko B, Szamatowicz J, et al. High Resistin And Interleukin-6 Levels Are Associated With Gestational Diabetes Mellitus. Gynecol Endocrinol 2009; 25(4): 258-63.
33. Oikonomou EK, Antoniades C. The Role Of Adipose Tissue In Cardiovascular Health And Disease. Nat Rev Cardiol 2019; 16(2): 83-99.
34. Landecho MF, Tuero C, Valenti V, et al. Relevance Of Leptin And Other Adipokines In Obesity-Associated Cardiovascular Risk. Nutrients 2019; 11(11): 2664.
35. Wang H, Chen DY, Cao J, et al. High Serum Resistin Level May Be An Indicator Of The Severity Of Coronary Disease In Acute Coronary Syndrome. Chin Med Sci J 2009; 24(3): 161-6.
36. Hu WL, Qiao SB, Hou Q, et al. Plasma Resistin Is Increased In Patients With Unstable Angina. Chin Med J 2007; 120(10): 871-5.
37. Park HK, Ahima RS. Resistin In Rodents And Humans. Diabetes Metab J 2013; 37(6): 404-14.
38. Reilly MP, Lehrke M, Wolfe ML, et al. Resistin Is An Inflammatory Marker Of Atherosclerosis In Humans. Circulation 2005; 111(7): 932-9.
39. Zhang Z, Xing X, Hensley G, et al. Resistin Induces Expression Of Proinflammatory Cytokines And Chemokines In Human Articular Chondrocytes Via Transcription And Messenger RNA Stabilization. Arthritis Rheum 2010; 62(7): 1993-2003.
40. Park HK, Kwak MK, Kim HJ, et al. Linking Resistin, Inflammation, And Cardiometabolic Diseases. Korean J Intern Med 2017; 32(2): 239-47.
41. Huber J, Kiefer FW, Zeyda M, et al. CC Chemokine And CC Chemokine Receptor Profiles In Visceral And Subcutaneous Adipose Tissue Are Altered In Human Obesity. J Clin Endocrinol Metab 2008; 93(8): 3215-21.
42. Xu Y, Ma M, Ippolito GC, et al. Complement Activation In Factor D-Deficient Mice. Proc Natl Acad Sci U S A 2001; 98(25): 14577-82.
43. Wang JS, Lee WJ, Lee IT, et al. Association Between Serum Adipsin Levels And Insulin Resistance In Subjects With Various Degrees Of Glucose Intolerance. J Endocr Soc 2019; 3(2): 403-10.
44. Al-Daghri NM, Al-Ajlan AS, Alfawaz H, et al. Serum Cytokine, Chemokine And Hormone Levels In Saudi Adults With Pre-Diabetes: A One-Year Prospective Study. Int J Clin Exp Pathol 2015; 8(9): 11587-93.
45. Wang Y, Zheng X, Xie X, et al. Correlation Of Increased Serum Adipsin With Increased Cardiovascular Risks In Adult Patients With Growth Hormon Defficiency. Endocr Pract 2019; 25(5): 446-53.
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GamarTalepoor A, Dowlatshahi E, Doroudchi M. Correlation of CCL18 with Levels of Adi-pokines in the Sera of Patients with Myocardial Infarction in a 6-Month Period: Case Series. Iran South Med J. 2020; 23 (3) :222-235
URL: http://ismj.bpums.ac.ir/article-1-1305-en.html

Volume 23, Issue 3 (Iranian South Medical Journal 2020) Back to browse issues page
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