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:: Volume 25, Issue 1 (Iranian South Medical Journal 2022) ::
Iran South Med J 2022, 25(1): 42-49 Back to browse issues page
Evaluating the Effect of Injected Dose of 99mTc- MIBI on the Quantitative Parameters of Myocardial Perfusion Imaging
Mehdi Haghighatafshar 1, Reza Fatheazam2, Tahereh Firuzyar1
1- Department of Nuclear Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
Nuclear Medicine and Molecular Imaging Research Center, Namazi Hospital, Shiraz University of Medical Sceinces, Shiraz, Iran
2- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (626 Views)
Background: 99mTc-MIBI cardiac perfusion scanning is recognized as a clinically useful method in evaluating coronary artery disease. By the implementation of new imaging techniques and systems, it seems possible to obtain high-quality images with a lower dose of radiopharmaceuticals. The purpose of this study was to evaluate the effect of injection dose of 99mTc-MIBI on quantitative parameters of cardiac perfusion scan.
Materials and Methods: Eighty-three patients with the known probability of coronary artery disease were imaged three times (15, 120, and 180 min) after one injection during the stress phase. Assuming that 99mTc-MIBI has not any significant redistribution at this time, the only parameter which has been changed is the amount of accumulated radioactivity within the myocardium. In this way, we have three different images with different deposited doses in the myocardium from each patient. Then quantitative data of End Systolic Volume (ESV), End Diastolic Volume (EDV), and Ejection Fraction (EF) were calculated and compared.
Results: Examination of quantitative scanning data indicates that the changes in EF data were non-significant and that the changes in ESV and EDV were significant over time.
Conclusion: In this study, assuming a dose reduction of radioactivity up to 50% of the initial dose based on cumulative dose in myocardial and imaging time, no clinically significant changes in quantitative cardiac perfusion scan variables such as ESV, EDV and EF occurred.
Keywords: Quantitative Myocardial Analysis, Myocardial Perfusion Imaging (MPI), Tc-99m-MIBI, Injected dose
Full-Text [PDF 433 kb]   (117 Downloads)    
Type of Study: Original | Subject: Radiology. Diagnostic Imaging
Received: 2020/01/26 | Accepted: 2022/02/19 | Published: 2022/03/13
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Haghighatafshar M, Fatheazam R, Firuzyar T. Evaluating the Effect of Injected Dose of 99mTc- MIBI on the Quantitative Parameters of Myocardial Perfusion Imaging. Iran South Med J. 2022; 25 (1) :42-49
URL: http://ismj.bpums.ac.ir/article-1-1546-en.html

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Volume 25, Issue 1 (Iranian South Medical Journal 2022) Back to browse issues page
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