[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Issue 1 (Iranian south medical Journal 2009) ::
Iran South Med J 2009, 12(1): 1-7 Back to browse issues page
Frequency of the most prevalent Thiopurine S-Methyl Trasferase alleles in referrals to Shariati Hospital in Tehran
Mehdi Azadi Mr1, Saeed Kaviani Mr *2, Masood Soleimani Mr3, Mehrdad Norouzi nia Mr3, Abbas Haji fathali Mr4
1- Ph.D
2- Assistant Professor , kavianis@gmail.com
3- Assistant Professor
4- Associated Professor
Abstract:   (11996 Views)
Background: Patients with low or intermediate TPMT enzyme activity are at increased risk to develop severe hematopoietic toxicity after taking standard doses of thiopuring medications. The aim of this study was to determine the frequency of four allelic variants of the TPMT gene in an Iranian population. Methods: In this cross sectional study, samples were obtained from 127 Iranian volunteers in Shariati hospital and were analyzed using PCR-RFLP and Allele Specific PCR techniques to determine the presence of common TPMT Polymorphisms in this population. Results: Mutant TPMT alleles were found in 11.8% of subjects (15 out of 127). Nine had TPMT*2, 4 TPMT *3C and 2 TPMT*3A. Conclusions: Our data showed the necessity of TPMT polymorphisms assessment before administration of thiopurine drugs.
Keywords: TPMT, Polymorphism, pharmaco genetics, Iranian population
Full-Text [PDF 411 kb]   (925 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/09/19 | Accepted: 2009/09/19 | Published: 2009/09/19
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Azadi M, Kaviani S, Soleimani M, Norouzi nia M, Haji fathali A. Frequency of the most prevalent Thiopurine S-Methyl Trasferase alleles in referrals to Shariati Hospital in Tehran. Iran South Med J. 2009; 12 (1) :1-7
URL: http://ismj.bpums.ac.ir/article-1-166-en.html
Volume 12, Issue 1 (Iranian south medical Journal 2009) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.048 seconds with 800 queries by yektaweb 3531