Volume 13, Issue 3 (Iranian South Medical Journal 2010)                   Iran South Med J 2010, 13(3): 207-215 | Back to browse issues page

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Najafi A, Abolkheir A R, Vahdat K, Nabipour I. Identification of Bioactive Agents and Immunomodulatory Factors from Seashells of the Persian Gulf . Iran South Med J 2010; 13 (3) :207-215
URL: http://ismj.bpums.ac.ir/article-1-224-en.html
Identification of Bioactive Agents and Immunomodulatory Factors from Seashells of the Persian Gulf
Arezoo Najafi , Amir Reza Abolkheir , Katayoun Vahdat , Iraj Nabipour *1
1- , inabipour@gmail.com
Abstract:   (23170 Views)
Background: Research in marine pharmacology will promise new bioactive agents. The marine bioenvironment is the unique resource for bioactive agents that could not be found in terrestrial organisms. Methods: A total of known 611 seashells species in the Persian Gulf were investigated for synonymy in OBIS database. Then, all the species, including their synonymy were searched in PubMed database to find their isolated bioactive agents. Results: From 611 known seashells in the Persian Gulf, 172 genera/species had bioactive compounds. Bioactive agents were isolated and purified for 16 genera/ species. The crude or purified extracts from these seashells had immunomodulatory effects (6 seashells), anti-toxicologic effects (4 seashells), analgesic (1 seashell), cardiotonic and vasoactive agents (2 seashells), hypolipidemic agents (4 seashells), anti-osteoporotic and osteoblastic agents (2 seashells) and anti-dermatitis effect (1 seashell). Conclusion: The known seashells from the Persian Gulf have bioactive and immunomodulatory compounds and increase in the efforts to isolate these agents will promise a treasure for novel anti-infective agents.
Keywords: seashell, immunity system, hypolipidemic, osteoporosis, anti-toxicologic
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Type of Study: Original | Subject: General
Received: 2010/04/3 | Accepted: 2010/04/27 | Published: 2010/08/11
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