Volume 28, Issue 3 (Iran South Med J 2025)
Iran South Med J 2025, 28(3): 666-674 |
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Habibi Daronkolayi K, Eslami Moayed M, Enayatrad M, Talebi A. Serum Vitamin D Levels and Their Association with Anti-Müllerian Hormone in Infertile Women. Iran South Med J 2025; 28 (3) :666-674
URL: http://ismj.bpums.ac.ir/article-1-2341-en.html
URL: http://ismj.bpums.ac.ir/article-1-2341-en.html
1- Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
2- Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
3- Clinical Research Development Unit, Bahar Hospital, Shahroud University of Medical Sciences, Shahroud, Iran
4- Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran ,alitalebi.ir@gmail.com
2- Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
3- Clinical Research Development Unit, Bahar Hospital, Shahroud University of Medical Sciences, Shahroud, Iran
4- Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran ,
Abstract: (198 Views)
Background: Anti-Müllerian hormone (AMH) is one of the most important biomarkers produced by granulosa cells and is measured as an indicator of ovarian reserve. Due to the contradictory findings of previous studies, the present study aimed to evaluate the serum concentration of vitamin D in a population of infertile women and its relationship with serum AMH levels.
Materials and Methods: The study population included infertile women who had undergone their treatment at the Shokoofeh Infertility Treatment Center in Shahroud. By reviewing patient medical records, serum levels of vitamin D and AMH were extracted from previous laboratory data. To assess the correlation between vitamin D and AMH levels in the study population, a regression analysis was performed in SPSS software (version 28).
Results: Among the infertile women examined, 37.2% (n=55) had vitamin D deficiency, while 62.8% (n=63) had normal vitamin D levels. The mean AMH level did not differ significantly between the two groups (normal vs. abnormal vitamin D). The overall mean AMH concentration was 1.9 ng/mL (±1.1). In the group with normal vitamin D levels, the mean AMH was 1.8 ±1.1 ng/mL, whereas in the group with abnormal vitamin D levels it was 1.9±1.2 ng/mL (p=0.396). No significant correlation was observed between vitamin D and AMH levels (p=0.120, Spearman’s r=0.017).
Conclusion: The findings of the present study align with those studies that have reported no association between vitamin D and AMH levels. Given the involvement of various factors in gene expression, it is possible that, despite vitamin D being considered a regulatory candidate, other factors may play a more influential role than vitamin D in regulating AMH expression.
Materials and Methods: The study population included infertile women who had undergone their treatment at the Shokoofeh Infertility Treatment Center in Shahroud. By reviewing patient medical records, serum levels of vitamin D and AMH were extracted from previous laboratory data. To assess the correlation between vitamin D and AMH levels in the study population, a regression analysis was performed in SPSS software (version 28).
Results: Among the infertile women examined, 37.2% (n=55) had vitamin D deficiency, while 62.8% (n=63) had normal vitamin D levels. The mean AMH level did not differ significantly between the two groups (normal vs. abnormal vitamin D). The overall mean AMH concentration was 1.9 ng/mL (±1.1). In the group with normal vitamin D levels, the mean AMH was 1.8 ±1.1 ng/mL, whereas in the group with abnormal vitamin D levels it was 1.9±1.2 ng/mL (p=0.396). No significant correlation was observed between vitamin D and AMH levels (p=0.120, Spearman’s r=0.017).
Conclusion: The findings of the present study align with those studies that have reported no association between vitamin D and AMH levels. Given the involvement of various factors in gene expression, it is possible that, despite vitamin D being considered a regulatory candidate, other factors may play a more influential role than vitamin D in regulating AMH expression.
Type of Study: Original |
Subject:
Gynecology
Received: 2025/09/9 | Accepted: 2025/11/25 | Published: 2025/12/27
Received: 2025/09/9 | Accepted: 2025/11/25 | Published: 2025/12/27
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