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:: Volume 14, Issue 3 (Iranian South Medical Journal 2011) ::
Iran South Med J 2011, 14(3): 179-184 Back to browse issues page
The role of Thymectomy in Remission of Myasthenia gravis patients with or without Thymoma
Manouchehr Aghajanzadeh, Seyed Ali Roudbari, Shahram Khadem, Mehdi Sakhabakhsh, Dina Emami, Sara Masahnia1
1- , smassahnia@yahoo.com
Abstract:   (39680 Views)

Background: Myasthenia gravis is an auto immune disease thymus have important role in this disease which Thymoma is the primary tumor of thymus that is produced by augmentation of epithelial cells inside of Glands. Thymectomy can improved myasthenia gravis disease. The main aim of this study is to assess the remission among the myasthenic patients after thymectomy. Methods: From 1993 to 2004, 68 patients who underwent thymectomy for mysthenia gravis were studied. Myathenia was established by positive electromyography and tensilon tests. These patients were operated by one surgeon at teaching and private hospitals, the specimens were tested by pathologist and patients were under follow up for 12 to 48 months. In following- up time the patient’s answer to remedy was basis to daily use of Mestinone and myasthenia crisis was investigated. Results: The age of the patients was 14 to 60years. The average age of the patients who was 34/08 years old. In 42 of patients was female and 26 was men. Between the men, 11 had complete remission 14 partial remission and one no answer. Between the female, 21 had complete remission. 19 partial remission and 2 no answer. This study had no inhospital mortality, but in follow up we 4/4% mortality seen. In pathology studies, 21 patients had thymoma, 45 had hyperplasia, and 2 had normal thymus. In 21 patients with thymoma, 11 had complete remission, 10 partial remissions. Between 45 patients with hyperplasia, 20 complete remission, 22 partial remission and 3 no answer. From two normal pathology reports, 1 complete and one partial remission. Conclusion: We conclude that thymectomy is a beneficial procedure for myasthenia gravis patients with a complete clinical remission rate in our series. Therefore we conclude thymectomy for myasthenia gravis patients is indicated as early as possible in the course of disease.

Keywords: myasthenia gravis, thymectomy, thymoma, hyperplasia, remission
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Type of Study: Original | Subject: General
Received: 2010/06/27 | Accepted: 2010/08/19 | Published: 2011/08/2
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Aghajanzadeh M, Roudbari S A, Khadem S, Sakhabakhsh M, Emami D, Masahnia S. The role of Thymectomy in Remission of Myasthenia gravis patients with or without Thymoma . Iran South Med J. 2011; 14 (3) :179-184
URL: http://ismj.bpums.ac.ir/article-1-272-en.html

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Volume 14, Issue 3 (Iranian South Medical Journal 2011) Back to browse issues page
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