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:: Volume 15, Issue 4 (Iranian South Medical Journal 2012) ::
Iran South Med J 2012, 15(4): 253-262 Back to browse issues page
High sensitive C-reactive protein and ischemic heart disease, a population- based study
Masoomeh Tohidi1, Mahsan Assadi2, Zeinab Dehghani1, Katayoun Vahdat1, Seyed Reza Emami1, Iraj Nabipour3
1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sceinecs, Bushehr, IRAN
2- The Persian Gulf Nuclear Medicine, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sceinecs, Bushehr, IRAN
3- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sceinecs, Bushehr, IRAN , inabipour@gmail.com
Abstract:   (15215 Views)

Background: The measurement of high sensitive C-reactive protein (hs-CRP) serum concentration has been suggested as an inflammatory agent in screening of high risk individuals for ischemic heart disease. The aim of this study was to investigate the relationship of this protein with ischemic heart disease in the northern Persian Gulf population. Material and Methods: In a cross-sectional study, 1615 (49.8% males, 50.2 % females) subjects over 25 years old were selected using a random cluster sampling technique in the northern Persian Gulf region. Cardiovascular risk factors in these subjects were studied according to WHO MONICA standard questionnaire. Minnesota code criteria’s were used in resting EKG to identify ischemic EKG. Serum level of hs-CRP was measured by ELISA. Results: Overall, 33.3 % of the participants had high levels of hs-CRP>3 mg/l. The geometrical means of hs-CRP in subjects with ischemic heart disease (2.96+3.75 mg/l) was higher than the normal subjects (1.84+3.84 mg/l) p(3mg/l and ischemic heart disease [Odds ratio= 1.67, CI95% (1.21-2.30) p = 0.002]. Conclusion: In over 25 years old of northern Persian Gulf population, hs-CRP was independently associated with ischemic heart disease. Thus, the measurement of hs-CRP in those who have intermediate risk for cardiovascular diseasess is recommended.

Keywords: C-reactive protein, cardiovascular disease, myocardial infarction, ischemia heart disease
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Type of Study: Original | Subject: General
Received: 2011/09/9 | Accepted: 2011/09/28 | Published: 2012/11/6
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Tohidi M, Assadi M, Dehghani Z, Vahdat K, Emami S R, Nabipour I. High sensitive C-reactive protein and ischemic heart disease, a population- based study . Iran South Med J. 2012; 15 (4) :253-262
URL: http://ismj.bpums.ac.ir/article-1-365-en.html


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Volume 15, Issue 4 (Iranian South Medical Journal 2012) Back to browse issues page
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