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:: Volume 9, Issue 1 (Iranian south medical of journals 2006) ::
Iran South Med J 2006, 9(1): 1-8 Back to browse issues page
The effect of antiviral activity of a green seaweed from the Persian Gulf, Caulerpa sertularioides on Herpes Simplex Virus Type 1
Keyvan Zandi Mr 1, Maryam Bahmanyar Ms, Kahzad Sartavi Mr
1- , zandi@dr.com
Abstract:   (10936 Views)
Background: By considering the daily increase in drug resistance of various viruses, novel antiviral compounds extracted from natural resources – due to their fewer side effects, had always been important to researchers. In the present study, we investigated antiviral activity of the hot water extract of a green seaweed, Caulerpa sertularioides, collected from coastal water of Bushehr in the Persian Gulf, against Herpes Simplex Virus Type 1 (HSV-1). Methods: The hot water extract of a green seaweed, Caulerpa sertularioides was sterilized by autoclave and filtration methods. After determining its cytotoxic concentration 50 (CC50) value, the effect of the extract on the inhibition of HSV-1 replication was examined in Vero cell culture. Results: The extract showed antiviral activity against HSV-1 in both attachment and entry of virus to the Vero cells and also on post attachment stages of virus replication. Inhibitory concentration 50 (IC50) values of the autoclaved extract were 81µg/ml and 126 µg/ml for attachment and post attachment stages, respectively. IC50 values of the filtered extract were 73 µg/ml and 104 µg/ml for attachment and post attachment stages, respectively. CC50 values for autoclaved and filtered extracts were 3140 µg/ml and 3095 µg/ml, respectively. Conclusion: The hot water extract of Caulerpa sertularioides of the Persian Gulf had antiviral effect against HSV-1.
Keywords: Caulerpa sertularioides, Herpes Simplex Virus Type 1, seaweed, infectivity
Full-Text [PDF 152 kb]   (1768 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/01/13 | Accepted: 2009/01/13 | Published: 2009/01/13
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Zandi K, Bahmanyar M, Sartavi K. The effect of antiviral activity of a green seaweed from the Persian Gulf, Caulerpa sertularioides on Herpes Simplex Virus Type 1. Iran South Med J. 2006; 9 (1) :1-8
URL: http://ismj.bpums.ac.ir/article-1-40-en.html


Volume 9, Issue 1 (Iranian south medical of journals 2006) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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