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:: Volume 16, Issue 3 (Iranian South Medical Journal 2013) ::
Iran South Med J 2013, 16(3): 207-214 Back to browse issues page
Effect of water coffee extract on kidney volume (a stereological study)
Farzaneh Dehghani 1, Abdol Rahman Dezfulian, Mohammad Reza Panjehshahin
1- Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Fars, IRAN , dehghanf@sums.ac.ir
Abstract:   (5982 Views)

Background: Coffee is a traditional drinking used by most of the people around the world. Overuse of coffee leads to many side effects on body. In this study, the effect of different doses of coffee extract on kidney volume was studied by the stereological method. Material and Methods: Sixty spragu-dawley male rats were divided into 6 groups. Control group was given tap water (0.5ml) and experimental groups were given coffee extract orally for 14 days with doses (0.125, 0.25, 0.5, 1, 1.5gr/kg) with the same volume of control group. Then rats were anesthetized (with ether), sacrificed and their right kidneys were removed, fixed, tissue processed and stained with H&E. The 5µm slides were studied by Cavalieri principle. Results: Higher doses of water coffee extract were associated with decreased kidney volume and volumes of glomerules but in lower doses it increased related to control group. Conclusion: It seems that, high doses of coffee has side effect on kidneyand reduces volume of kidney and its glomerules. However further studies are required to confirm this research.

Keywords: coffeine, stereology, kidney, glomerule
Full-Text [PDF 310 kb]   (1454 Downloads)    
Type of Study: Original | Subject: General
Received: 2013/07/16 | Accepted: 2013/07/16 | Published: 2013/07/16
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Dehghani F, Dezfulian A R, Panjehshahin M R. Effect of water coffee extract on kidney volume (a stereological study). Iran South Med J. 2013; 16 (3) :207-214
URL: http://ismj.bpums.ac.ir/article-1-444-en.html


Volume 16, Issue 3 (Iranian South Medical Journal 2013) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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