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Efficacy of intramuscular single dose of ceftriaxon versus ten days amoxicillin for treatment of children with acute otitis media
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| Ali Akbar Rahbari manesh, Afshin Shirkani1, Hooshang Akhtar Khavari, Peyman Salamaty |
| 1- , shirkani@Razi.tums.ac.ir |
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Abstract: (12210 Views) |
| Background: Ceftriaxone is a prolonged third-generation cephalosporin and its intramuscular single dose can provide the necessary serum level against typical pathogens of acute otitis media up to 72 hours. Methods: In a prospective, randomized clinical trial study, the efficacy of intramuscular single dose of ceftriaxone (50mg/kg/dose) was compared to 10 days amoxicillin (50mg/kg/day, divided 3 time per day) to treat acute otitis media in children. A total of 110 children aged 5 months to 12 years, with uncomplicated acute otitis media were randomly selected to receive either an oral suspension amoxicillin for 10 days or an intramuscular single dose of ceftriaxone. Results: Clinical manifestation and demographic characteristics were similar in both groups. In ceftriaxone group, 48 (88.9%) of 54 cases were recovered completely, and in amoxicilline group, the treatment was successful in 51 (99.1%) of 56 cases (p>0.05). In ceftriaxone, 2 cases and in amoxicilline group, 3 cases developed a skin rash (p>0.05). Conclusion: The efficacy of intramuscular single dose of ceftriaxone (50mg/kg) to treat uncomplicated acute otitis media in children is as effective as amoxicillin (50mg/kg/day, divided 3 times per day). |
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| Keywords: ceftriaxone, amoxicillin, acute otitis media, antibiotic |
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Full-Text [PDF 164 kb]
(1860 Downloads)
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Type of Study: Original |
Subject:
General
Received: 2006/11/25 | Accepted: 2007/07/6 | Published: 2008/08/31
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