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:: Volume 18, Issue 1 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(1): 117-124 Back to browse issues page
Investigation of E-cadherin expression in Peripheral Blood of patients with breast cancer in a population from southern Iran
Sisrous Naeimi1, Ali M.Ardekani2, Abbas Ghaderi3, Nasrola Erfani 4
1- Department of biology, Collage of Science, Tehran Science and Research branch, Islamic Azad University, Tehran, Iran
2- Department of Molecular Genetic, National Institute of Genetic engineering and Biotechnology (NIGEB), Tehran, Iran
3- Department of Cancer Immunology, Shiraz Institute for Cancer Research , School of medicine, Shiraz University of medical sciences, Shiraz, Iran
4- Department of Cancer Immunology, Shiraz Institute for Cancer Research , School of medicine, Shiraz University of medical sciences, Shiraz, Iran , erfanin@sums.ac.ir
Abstract:   (4088 Views)

Background: Breast cancer is the most common malignancy in women, and is considered as the second causative factor in cancer mortality. E – Cadherin is a transmember glycoprotein and play a essential role in cell-cell adhesion .It seems that E-cadherin Gene expression can plays a role in suppressor of invasion and metastasistumor . The aim of this study was to evaluate the correlation of E-cadherin Gene expression with breast cancer in the women population of southern Iran. Materials and Methods: 30 patients and 30 healthy individuals as control participated in this case-control study. mRNA extracted from peripheral blood. Real Time PCR technique was used to determine the Gene expression. The statistical analysis was performed by the software SPSS and Mannwithny test . Results: The results indicated that there is no significant difference in level of E- cadherin Gene expression in patients with breast cancer and the control group (Pv>0.05). Furthermore, we found no significant correlation between the E- cadherin Gene expression with the clinicopathological factors in the patients. Conclusion: it seems that E- cadherin Gene expression, plays no important role in increasing the susceptibility of women to breast cancer in the population of southern Iran.

Keywords: Breast cancer, Gene expression, E- cadherin, Cell –cell adhesion
Full-Text [PDF 431 kb]   (1954 Downloads)    
Type of Study: Original | Subject: Pathology
Received: 2015/02/18 | Accepted: 2015/02/18 | Published: 2015/02/18
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Naeimi S, M.Ardekani A, Ghaderi A, Erfani N. Investigation of E-cadherin expression in Peripheral Blood of patients with breast cancer in a population from southern Iran. Iran South Med J. 2015; 18 (1) :117-124
URL: http://ismj.bpums.ac.ir/article-1-655-en.html


Volume 18, Issue 1 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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