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:: Volume 8, Issue 2 (Iranian south medical of journals 2006) ::
Iran South Med J 2006, 8(2): 134-142 Back to browse issues page
Improving adherence with deferoxamine regimen in thalassemia major using education
Gholamreza Pouladfar Mr *1, Mandana Moaiedfard Ms2
1- Assistant Professor , pooladfar@sums.ac.ir
2- Dr
Abstract:   (8935 Views)
Background: Subcutaneous deferoxamine is the first line for management of iron overload in thalassemia major. There is a wide deferoxamine adherence variation in patients with thalassemia major. In order to assess the effect of education on patients and their parents, a cognitive approach was used. Methods: In a randomized control trial, 78 consecutive patients with thalassemia major were randomly divided into educational (38 cases, 50% male and 50% female) and control (40 cases, 65% male and 35% female) groups. Oral and practical education sessions for deferoxamine injection were planned. Deferoxamine usage, pump function, side effects, knowledge levels of the patients and their parents, and ferritin serum levels were assessed before and after the trail. The knowledge was also evaluated promptly after educational sessions. Results: the mean age of experimental and control groups were 14.6 and 13.0 years, respectively. There was no significant difference in age, sex and weight (P>0.05) at the end of the study, there was no significant change in the level of knowledge in both groups however, the patients who used deferoxamine at least 5 times a week were increased in the experimental group (P<0.05). Pain, irritation, redness and edema at local injection sites were reported lesser by experimental subjects after education (P<0.01), but the frequency of these local complications did not change in the control group (P>0.05). Both groups reported improvement in pump function (P>0.001). Conclusion: A cognitive approach had relatively significant effect on deferoxamine adherence. However, educational sessions had not dramatic change in knowledge levels of the patients and their parents, but oral and practical education produced a significant change in decreasing local side effects of subcutaneous deferoxamine in thalassemia major.
Keywords: thalassemia major, deferoxamine, drug adherence, education
Full-Text [PDF 6571 kb]   (1513 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/01/15 | Accepted: 2009/01/15 | Published: 2009/01/15
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DOI: 10.19082/2425
PMID: 27382454
PMCID: PMC4930264


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Pouladfar G, Moaiedfard M. Improving adherence with deferoxamine regimen in thalassemia major using education. Iran South Med J. 2006; 8 (2) :134-142
URL: http://ismj.bpums.ac.ir/article-1-68-en.html
Volume 8, Issue 2 (Iranian south medical of journals 2006) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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