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:: Volume 18, Issue 3 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(3): 527-537 Back to browse issues page
Effect of 8 weeks resistance training on plasma levels of nerve growth factor and interlukin-6 in female patients with multiple sclerosis
Mehrzad Moghadasi 1, Mohammadamin Edalatmanesh2, Ayda Moeini3, Mohadeseh sadat Nematollahzadeh mahani3, Hamid Arvin4
1- Department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran , moghadasi39@yahoo.com
2- Department of physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
3- Education Organization of Fars Province, Fars, Iran
4- Department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
Abstract:   (4680 Views)

Background: In recent years, evidence from a number of studies has suggested that exercise is a safe and efficient way to induce improvements in a number of physiological functions in multiple sclerosis (MS) patients, but the effects of exercise on nerve growth factor (NGF) and interlukin-6 (IL-6) in these patients are not well known. Thus, the purpose of this study was to evaluate the effect of 8 weeks resistance training on plasma NGF and IL-6 in female patients with MS. Materials and methods: Thirty two female MS patients with 32.4±5.5 years of old, and expanded disability status scale (EDSS) 0-4.5, participated in this study. The subjects were randomly assigned to control group (n=13) and training group (n=14). Subjects in training group performed selected upper and lower extremities resistance training with weight-training equipment and rubber bands 3 days a week for 8 weeks. Body composition parameters, NGF and IL-6 levels were measured before and after the intervention. Results: The results showed that body weight, body mass index, body fat mass and EDSS were decreased significantly after 8 weeks in training group compared to control group (P<0.05). Also, no significant differences were seen after the intervention in NGF and IL-6 between the training and control groups. Conclusion: The results suggest resistance training with specific intensity and duration utilized in this study improves EDSS in female patients with MS but it has no effecting on NGF and IL-6 in these patients.

Keywords: Resistance training, Multiple sclerosis, nerve growth factor, interlukin-6
Full-Text [PDF 663 kb]   (2276 Downloads)    
Type of Study: Original | Subject: Nervous System
Received: 2013/08/7 | Accepted: 2014/05/29 | Published: 2015/06/28
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Moghadasi M, Edalatmanesh M, Moeini A, Nematollahzadeh mahani M S, Arvin H. Effect of 8 weeks resistance training on plasma levels of nerve growth factor and interlukin-6 in female patients with multiple sclerosis. Iran South Med J. 2015; 18 (3) :527-537
URL: http://ismj.bpums.ac.ir/article-1-699-en.html


Volume 18, Issue 3 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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