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:: Volume 18, Issue 3 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(3): 567-574 Back to browse issues page
Investigation of the effects of tumor size and type of radionuclide on tumor curability in targeted radiotherapy
Hassan Ranjbar 1, Ali Bahrami Samani2, Mohammad Ghannadi Maragheh2, Davood Beiki3
1- Department of Radiochemistry, Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, Iran , hranjbar@aeoi.org.ir
2- Department of Radiochemistry, Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
3- Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:   (3963 Views)

Background: Targeted radiotherapy is one of the important methods of radiotherapy that involves the use of beta-emitting radionuclides to deliver a dose of radiation to tumor cells. An important feature of this method is the tumor size and the finite range of beta particles emitted as a result of radionuclide disintegration those have significant effects for the curability of tumors. Material and Methods: Monte Carlo simulations and mathematical models have been used to investigate the relationship of curability to tumors size for tumors treated with targeted 131I and 90Y. The model assumed that radionuclides are distributed uniformly throughout tumors. Results: The results show that there is an optimal tumor size for cure. For any given cumulated activity, cure probability is greatest for tumors whose diameter is close to the optimum value. There is a maximum value of curability that occurs at a diameter of approximately 3.5 mm for 131I. For 90Y maximum curability occurs at a tumor diameter of approximately 3.5 cm. Tumors smaller than the optimal size are less vulnerable to irradiation from radionuclides because a significant proportion of the disintegration energy escapes and is deposited outside the tumor volume. Tumors larger than the optimal size are less curable because of greater clonogenic cell number. Conclusion: With single radionuclide targeted radiotherapy, there is an optimal tumor size for tumor cure. It is suggested that single agent targeted radiotherapy should not be used for treatment of disseminated disease when multiple tumors of differing size may be present. The use of several radionuclides concurrently would be more effective than reliance on single radionuclide. This approach of using combination of radionuclides with complementary properties could hopefully prepare new measures and improve the efficiency of tumor therapy.

Keywords: Targeted radiotherapy, Tumor curability, absorbed fraction, I-131, Y-90
Full-Text [PDF 543 kb]   (2327 Downloads)    
Type of Study: Original | Subject: Pathology
Received: 2014/05/22 | Accepted: 2014/07/14 | Published: 2015/06/28
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Ranjbar H, Bahrami Samani A, Ghannadi Maragheh M, Beiki D. Investigation of the effects of tumor size and type of radionuclide on tumor curability in targeted radiotherapy. Iran South Med J. 2015; 18 (3) :567-574
URL: http://ismj.bpums.ac.ir/article-1-703-en.html


Volume 18, Issue 3 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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