[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 18, Issue 3 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(3): 607-629 Back to browse issues page
Marine bioactive peptides with anti-cancer potential
Mohammad Nazarian1, Seyed Javad Hosseini2, Iraj Nabipour3, Gholamhosean Mohebbi3
1- Department of cellular and molecular sciences, faculty of basic sciences, the Persian Gulf University, Bushehr, Iran
2- Department of cellular and molecular sciences, faculty of basic sciences, the Persian Gulf University, Bushehr, Iran
Department of Biotechnology, The Persian Gulf Research and Studies Center, The Persian Gulf University, ,Bushehr, Iran , mohebbihsn@yahoo.com
3- Department of toxinology, The Persian Gulf Marine Biotechnology Research Center, the Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract:   (6294 Views)

In the developing world, the cancer as a prevalent cause of mortality is a new emerging challenges in medical and pharmaceutical sciences. Marine environs are regarded as a rich source of natural products with broad of therapeutic uses. Numerous bioactive peptides and depsi-peptides have been extracted from various marine organisms such as tunicates, sponges, molluscs and other marine organisms, with anti-cancer potential. They can produce the complex compounds which are more effective than presented anti-cancer drugs. Some of these marine peptides are under different clinical trials phases they are secondary metabolites that produced by these organisms. According to different studies, their anti-cancer potential is related to some properties like antioxidant, anti- proliferative and anti-mutations effects. These peptides can stimulate cell death by various mechanisms, such as apoptosis, affecting the balance tubulin- microtubules (antimicrotubules), inhibition of angiogenesis, antiproliferative and cytotoxicity effects. Further studies on the reaction states of these compounds on cell cycle or apoptosis in cancer cells, are essential. The future of remedies, belong to the sea and the sea, will have the major percentage in drug discovery, particularly in anti-cancer drugs.

Keywords: bioactive peptides, anti-cancer drugs, marine organisms
Full-Text [PDF 1158 kb]   (2257 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2015/02/9 | Accepted: 2015/04/30 | Published: 2015/06/28
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nazarian M, Hosseini S J, Nabipour I, Mohebbi G. Marine bioactive peptides with anti-cancer potential. Iran South Med J. 2015; 18 (3) :607-629
URL: http://ismj.bpums.ac.ir/article-1-707-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 3 (Iranian South Medical Journal 2015) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2022, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4419