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:: Volume 18, Issue 6 (Iranian South Medical Journal 2016) ::
Iran South Med J 2016, 18(6): 1132-1139 Back to browse issues page
Study of Fas 1377 G˃A polymorphism in breast cancer of Iranian patients
Zahra Tahmasbifard *1, Mandana Hasanzad 2, Nahid Nafisi 3
1- Department of Molecular and Cell Biology, Advanced sciences ,Islamic Azad University, Tehran Medical Sciences Branch. Tehran, Iran , ztahmasebi@riau.ac.ir
2- Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
3- Oncoplastic Breast Surgery , Cancer Research Center, Shahidbeheshti University of Medical Sciences, Tehran, Iran
Abstract:   (1991 Views)

Background: Apoptosis or programmed cell death is essential for developing and tissue repair. Apoptosis stimulates by binding fas to fas ligand that plays an important role in regulation of the immune system. There are Conflicting data on the association between 1377 polymorphisms and susceptibility to cancer. This study has been conducted to investigation the relationship between polymorphism 1377 A / G in the Fas gene and breast cancer of Iranian patients.

Materials and Methods: 65 patients with breast cancer and 57 control subjects were studied. In this study, PCR-RFLP method was used to determine genotypes. Statistical analysis software SPSS 19, by two-dimensional tables X2 test with 99% confidence intervals were calculated .

Results: The results were showed that the genotype AA 70.7%, GG 27.7%, AG 1.53% of breast carcinoma samples and genotypes AA 56.1%, GG 17.5%, AG 26.3% prevalence among the controls. Also according to Hardy-Weinberg equilibrium, the frequency of allele A in cancer patients was 71.5% and the frequency of G was 28.5% and the frequency of allele A in control subjects was 69.3% and for allele G 30.7% was calculated. Statistically significant relationship was observed between the two groups. (P-Value ˃0.01)

Conclusion: According to the findings of this study, polymorphism 1377 G / A in Fas gene were associated with susceptibility to breast cancer, and it can be considered as a factor in breast carcinogenesis.

Keywords: Fas 1377 G / A, polymorphism, breast cancer, RFLP-PCR
Full-Text [PDF 686 kb]   (559 Downloads)    
Type of Study: Original | Subject: Clinical Laboratory Pathology
Received: 2015/12/22 | Accepted: 2015/12/22 | Published: 2015/12/22
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DOI: 10.7508/ismj.1394.06.003


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Tahmasbifard Z, Hasanzad M, Nafisi N. Study of Fas 1377 G˃A polymorphism in breast cancer of Iranian patients. Iran South Med J. 2016; 18 (6) :1132-1139
URL: http://ismj.bpums.ac.ir/article-1-746-en.html
Volume 18, Issue 6 (Iranian South Medical Journal 2016) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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