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:: Volume 19, Number 3 (Iranian South Medical Journal 2016) ::
Iran South Med J 2016, 19(3): 372-384 Back to browse issues page
The effects of testosterone intrauterine disturbance on sperm quality and testis tissue in male rat's offspring after puberty
Mahsa Noroozzadeh1, Fahemeh Ramezani Tehrani *2, Azita Zadeh-Vakili3, Abbas Piryaei4, Asghar Ghasemi5, Fereydoun Azizi6
1- Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , ramezani@endocrine.ac.ir
3- Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Department of Biology and Anatomical Sciences, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (1266 Views)

Background: Environmental factors and hormonal disorders during prenatal life can impair the evolution and differentiation of fetus’s reproductive system. The aim of this study was to the examination of sperm quality and testis tissue in adult rats that had exposed to exogenous testosterone during their prenatal life.

Materials & Methods: Pregnant rats divided into two experimental and control groups. In experimental group, pregnant rats daily were subcutaneously injected with 3 mg exogenous testosterone during gestational days
16-19, and controls received solvent. The reproductive system was examined in male offspring of these animals after puberty. Data analysis was performed by using the SPSS software (version 15). Distributions between groups are compared by using the Mann-Whitney test.

Results: In the offspring of experimental group, motility and the number of sperm were significantly decreased (P<0.05). No morphological abnormality was observed in sperm in two groups. The numbers of sertoli cells, ratios of spermatocyte and round spermatid cells were significantly decreased in the offspring of experimental group (P<0.05). No significant difference was observed in seminiferous tubules diameter between the two groups. Serum testosterone levels were significantly decreased in offspring from experimental group (P<0.05).

Conclusion: The present study showed that prenatal exposure to testosterone leads to decrease of sperm quality and changes in testis tissue in male rats, after puberty.

Keywords: Prenatal life, Testosterone, Sperm quality, Testis, Rat
Full-Text [PDF 621 kb]   (464 Downloads)    
Type of Study: Original | Subject: Gynecology
Received: 2016/07/17 | Accepted: 2016/07/17 | Published: 2016/07/17
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DOI: 10.18869/acadpub.ismj.19.3.372


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Noroozzadeh M, Ramezani Tehrani F, Zadeh-Vakili A, Piryaei A, Ghasemi A, Azizi F. The effects of testosterone intrauterine disturbance on sperm quality and testis tissue in male rat's offspring after puberty. Iran South Med J. 2016; 19 (3) :372-384
URL: http://ismj.bpums.ac.ir/article-1-801-en.html
Volume 19, Number 3 (Iranian South Medical Journal 2016) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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