[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 19, Number 4 (Iranian South Medical Journal 2016) ::
Iran South Med J 2016, 19(4): 629-643 Back to browse issues page
Association between COX-2 A1195G polymorphism with migraine in patients with consanguineous marriage of parents
Elahe Mozaffari *1, Mostafa faghani2, Reza Nemati3, Morteza Makhlooei4
1- Department of Genetics, Faculty of Sciences, Islamic Azad University of Shahrekord branch, Shahrekord, Iran , elahehsea@yahoo.com
2- Department of Animal Sciences and Fisheries, Faculty of Agricultural Sciences, Islamic Azad University of Shahrekord branch, Shahrekord, Iran
3- Department of Neurology, School of Medicine, Boushehr University of Medical Sciences, Boushehr,Iran
4- Department of Fishery, Faculty of Agricultural Sciences and Natural Resources, Islamic Azad University of Boushehr branch, Boushehr, Iran
Abstract:   (1005 Views)

Background: Migraine is a common debilitating headache with current head pain attacks which associated with temporal changes of head blood vessels diameter and  has been classified into two main categories, migraine with aura (MA) and migraine without aura (MO) by the International criteria for Headache Society (IHS). This study was performed with the aim of studying the association of COX-2-1195A G gene polymorphism, risk of migraine susceptibility and  it’s relation with parent marriage type in two control and case groups.

Materials and Methods: Genomic DNA of blood samples was purified from 100 migraine cases and 100 controls in this study. By using the appropriative COX-2-1195A→G (rs89466) primer and Pvu II restriction enzyme in PCR- RFLP manner the expected region of subject’s COX-2 gene was amplified and digested.

Results: After analysising the data with SPSS twentieth version software, it was observed that frequency of COX-2-1195 GG and COX-2-1195 AG genotypes carriers in patients were higher than in the controls (9 percent and 41 percent in migraine cases, 5 percent and 24 percent in controls respectively; (P>0.010)), also it was specificated that frequences of mentioned genotypes has been significantly higher in patients with relative parent than in control group (8.1 percent and 48.6 percent in cases with relative parent, 5 percent and 24 percent in controls respectively; (P>0.011)).

Conclusion: Regarding high frequency of polymorph allele (G) in between patients with consanguineous parents, it can be resulted that consanguineous marriage increase the risk of this allele incidence and migraine outbreak. So, further studies with larger sample groups are needed on different nations of other regions to achieve better results about genetic of migraine, especially COX-2 gene.

Keywords: Migraine, Polymorphism, COX-2 gene, consanguineous marriage
Full-Text [PDF 357 kb]   (341 Downloads)    
Type of Study: Original | Subject: Biochemistry. Cell Biology and Genetics
Received: 2016/09/7 | Accepted: 2016/09/7 | Published: 2016/09/7
References
1. Chasman DI, Schürks M, Anttila V, et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 2011; 43(7): 695-8. [PubMed] [Google Scholar]
2. Dasdemir S, Cetinkaya Y, Gencer M, et al. Cox-2 gene variants in migraine. Gene 2013; 518(2): 292-5. [PubMed] [Google Scholar]
3. Goadsby PJ, Lipton RB, Ferrari MD. Migraine-current understanding and treatment. N Engl J Med 2002; 346(4): 257-70. [PubMed] [Google Scholar]
4. McCrary D, McClain D, Criscuolot C. The Molecular Genetics of MigraineHeadaches and their Catalytic NatureTowards Strokes; 2001.
5. Kara I, Sazci A, Ergul E, et al. Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 2003; 111(1-2): 84-90. [PubMed] [Google Scholar]
6. Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders. 2nd ed. United Kingdom: Cephalalgia 2004, 9-160. [Google Scholar]
7. Kelman L, Tanis D. The relationship between migraine pain and other associated symptoms. Cephalalgia 2006; 26(5): 548-253. [PubMed] [Google Scholar]
8. Aghayusefi AR, Bazyari Meymand. Study of General health, resiliency, and defense mechanisms in patients with migraine headache. Iran South Med J 2013; 16(2): 118-27. (Persian) [Google Scholar]
9. Freilinger T, Anttila V, de Vries B, et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet 2012; 44(7): 777-82. [PubMed] [Google Scholar]
10. Mulder EJ, van Baal C, Gaist D, et al. Genetic and environmental influences on migraine: a twin study across six countries. Twin Res 2003; 6(5): 422-31. [PubMed] [Google Scholar]
11. Gervil M, Ulrich V, Kaprio J, et al. The relative role of genetic and environmental factors in migraine. Neurology 1999; 53(5): 995-9. [PubMed] [Google Scholar]
12. Cutrer FM, Huerter K. Migraine aura. Neurologist 2007; 13(3): 118-25. [PubMed] [Google Scholar]
13. Evans RW, Bigal ME, Grosberg B, et al. Target doses and titration schedules for migraine preventive medications. Headache 2006; 46(1): 160-4. [PubMed] [Google Scholar]
14. Todt U, Dichgans M, Jurkat-Rott K, et al. Rare missense variants in ATP1A2 in families with clustering of common forms of migraine. Hum Mutat 2005; 26(4): 315-21. [PubMed] [Google Scholar]
15. Eikermann-Haerter K, Lee JH, Yuzawa I, et al. Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations. Circulation 2012; 125(2): 335-45. [PubMed] [Google Scholar]
16. Kurth T, Chabriat H, Bousser MG. Migraine and stroke: a complex association with clinical implications. Lancet Neurol 2012; 11(1): 92-100. [PubMed] [Google Scholar]
17. Butt JH, Franzmann U, Kruuse C. Endothelial function in migraine with aura-a systematic review. Headache 2015; 55(1): 35-54. [PubMed] [Google Scholar]
18. Asadi M, Saghari M, Eftekhari M, et al. Comparison of brain perfusion SPECT abnormalities with anatomical imaging in mild traumatic brain injury. Iran South Med J 2006; 9(2): 147-53. (Persian) [Google Scholar]
19. Griffiths LR, Nyholt DR, Curtain RP, et al. Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism. Neurology 1997; 49(2): 614-7. [PubMed] [Google Scholar]
20. Bresalier RS, Sandler RS, Quan H, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005; 352(11): 1092-102. [PubMed] [Google Scholar]
21. Silberstein S, Tepper S, Brandes J, et al. Randomized, placebo-controlled trial of rofecoxib in the acute treatment of migraine. Neurology 2004; 62(9): 1552-7. [PubMed] [Google Scholar]
22. Zhang X, Miao X, Tan W, et al. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology 2005; 129(2): 565-76. [PubMed] [Google Scholar]
23. Sanak M, Szczeklik W, Szczeklik A. Association of COX-2 gene haplotypes with prostaglandins production in bronchial asthma. J Allergy Clin Immunol 2005; 116(1): 221-3. [PubMed]
24. Bresalier RS, Sandler RS, Quan H, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005; 352(11): 1092-102. [PubMed] [Google Scholar]
25. Upadhyay R, Jain M, Kumar S, et al. Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. Mutat Res 2009; 663(1-2): 52-9. [PubMed] [Google Scholar]
26. Cetin M, Buyukberber S, Demir M, et al. Overexpression of cyclooxygenase-2 in multiple myeloma: association with reduced survival. Am J Hematol 2005; 80(3): 169-73. [PubMed] [Google Scholar]
27. Trojan A, Tinguely M, Vallet S, et al. Clinical significance of cyclooxygenase-2 (COX-2) in multiple myeloma. Swiss Med Wkly 2006; 136(25-26): 400-3. [PubMed] [Google Scholar]
28. Lopez-Campos JL, Rodriguez-Rodriguez D, Rodriguez-Becerra E, et al. Cyclooxygenase-2 polymorphisms confer susceptibility to sarcoidosis but are not related to prognosis. Respir Med 2009; 103(3): 427-33. [PubMed] [Google Scholar]
29. Samad TA, Moore KA, Sapirstein A, et al. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001; 410(6827): 471-5. [PubMed] [Google Scholar]
30. Campa D, Zienolddiny S, Maggini V, et al. Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis 2004; 25(2): 229-35. [PubMed] [Google Scholar]
31. Esmaeili B, Rezaee SA, Layegh P, et al. Expression of IL-17 and COX2 gene in peripheral blood leukocytes of vitiligo patients. Iran J Allergy Asthma Immunol 2011; 10(2): 81-9. [PubMed] [Google Scholar]
32. Li M, Gao Y, Li C, et al. Association of COX2 functional polymorphisms and the risk of vitiligo in Chinese populations. J Dermatol Sci 2009; 53(3): 176-81. [PubMed] [Google Scholar]
33. Fujita H, Koshida K, Keller ET, et al. Cyclooxygenase-2 promotes prostate cancer progression. Prostate 2002; 53(3): 232-40. [PubMed] [Google Scholar]
34. Kirschenbaum A, Klausner AP, Lee R, et al. Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostate. Urology 2000; 56(4): 671-6. [PubMed] [Google Scholar]
35. Daraei A, Salehi R, Mohamadhashem F. PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population. Mol Biol Rep 2012; 39(5): 5219-24. [PubMed] [Google Scholar]
36. Andersen V, Holst R, Kopp TI, et al. Interactions between diet, lifestyle and IL10, IL1B, and PTGS2/COX-2 gene polymorphisms in relation to risk of colorectal cancer in a prospective Danish case-cohort study. PLoS One 2013; 8(10): e78366. [PubMed] [Google Scholar]
37. Oka A, Takashima S. Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons. Neuroreport 1997; 8(5): 1161-4. [PubMed] [Google Scholar]
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



DOI: 10.18869/acadpub.ismj.19.4.629


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mozaffari E, faghani M, Nemati R, Makhlooei M. Association between COX-2 A1195G polymorphism with migraine in patients with consanguineous marriage of parents. Iran South Med J. 2016; 19 (4) :629-643
URL: http://ismj.bpums.ac.ir/article-1-820-en.html
Volume 19, Number 4 (Iranian South Medical Journal 2016) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

Iranian South Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License which allows users to read,
copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly

Copyright © 2017, Iranian South Medical Journal| All Rights Reserved

Persian site map - English site map - Created in 0.049 seconds with 829 queries by yektaweb 3461