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:: Volume 19, Number 5 (Iranian South Medical Journal 2016) ::
Iran South Med J 2016, 19(5): 799-808 Back to browse issues page
The Comparison of Schwann Cells Transplantation Effect with Autograft Model in Peripheral Nerve Regeneration in Animal Model
Sam Zarbakhsh *1, Nasrin Khanmohammadi2, Mehrdad Bakhtiari3
1- Research Center of Nervous System Stem Cells, Dept. of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran , smzarbakhsh@gmail.com
2- Research Center of Nervous System Stem Cells, Dept. of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
3- Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (930 Views)

Background: Transplantation of Schwann cells can facilitate the regeneration of peripheral nerves. The aim of this study was to comparison of Schwann cells transplantation effect with autograft model in peripheral nerve regeneration in animal model.

Materials and Methods: 20 male Wistar rats were randomly were divided into 3 groups: control, Schwann cells transplantation and autograft model. In the control group, a 10 mm segment of the left sciatic nerve was removed and a silicone tube replaced into this nerve gap. In the Schwann cells transplantation group, after placing the silicone tube were transplanted into the tubeabout 500,000 Schwann cells. In the autograft model group, 10 mm segment of the left sciatic nerve is removed and it was implanted to the two nerve endings after reversing. 12 weeks after surgery we evaluated the number of axons, the number of blood vessels and the restored myelin sheath thickness.

Results: Histological analysis by using one way ANOVA showed that the number of axons and the thickness of myelin sheath in autograft model group was significantly greater than the other groups, and in the Schwann cells transplantation group was significantly greater than the control group. Moreover, the number of restored blood vessels in the Schwann cells transplantation group was significantly greater than the other groups (P<0.05).

Conclusion: The results show that Schwann cells transplantation is effective in peripheral nerve regeneration and it may be a good alternative to autograft method.

Keywords: Autograft, Schwann cells, transplantation, peripheral nerve
Full-Text [PDF 578 kb]   (250 Downloads)    
Type of Study: Original | Subject: Nervous System
Received: 2016/11/17 | Accepted: 2016/11/17 | Published: 2016/11/17
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DOI: 10.18869/acadpub.ismj.19.5.799


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Zarbakhsh S, Khanmohammadi N, Bakhtiari M. The Comparison of Schwann Cells Transplantation Effect with Autograft Model in Peripheral Nerve Regeneration in Animal Model. Iran South Med J. 2016; 19 (5) :799-808
URL: http://ismj.bpums.ac.ir/article-1-828-en.html
Volume 19, Number 5 (Iranian South Medical Journal 2016) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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