Volume 19, Issue 6 (Iranian South Medical Journal 2017)
Iran South Med J 2017, 19(6): 1011-1021 |
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Darabi H, Behzadi Z, Zahedi T, Pourbehi M, Akbarzadeh S, Ostovar A, et al . The Correlation of Adiponectin, and Visfatin Serum Levels With Ischemic Heart Disease in Postmenopausal women: A population-Based Study. Iran South Med J 2017; 19 (6) :1011-1021
URL: http://ismj.bpums.ac.ir/article-1-850-en.html
URL: http://ismj.bpums.ac.ir/article-1-850-en.html
Hossein Darabi1 
, Zahra Behzadi1 , Taliaeh Zahedi1 , Mohammadreza Pourbehi1 , Samad Akbarzadeh1 , Afshin Ostovar1 , Majid Assadi2 , Mohammad Javad Haerinejad1 , Zahra Sanjideh1 , Iraj Nabipour * 3
, Zahra Behzadi1 , Taliaeh Zahedi1 , Mohammadreza Pourbehi1 , Samad Akbarzadeh1 , Afshin Ostovar1 , Majid Assadi2 , Mohammad Javad Haerinejad1 , Zahra Sanjideh1 , Iraj Nabipour * 3
1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , inabipour@gmail.com
2- The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , inabipour@gmail.com
Abstract: (5831 Views)
Background: There is a controversial evidence about adiponectin role in cardiovascular diseases and visfatin role has been suggested in pathogenesis of coronary artery disease.
Material and Methods: A total of 378 postmenopausal women were randomly selected from 13 clusters in Bushehr Port. The prevalence of ischemic heart disease was assessed by using the Minnesota Code with a 12-lead resting electrocardiogram (EKG). Serum adiponectin and visfatin levels were measured by using enzyme-linked immunosorbent assay methods
Results: A total of 159 patients (41.8 percent) were suffering from ischemic heart disease. There was no significant difference between women with ischemic heart disease and healthy postmenopausal women in adiponectin serum level. However, diabetic women with ischemic heart disease, compared with healthy postmenopausal women had a higher level of visfatin (Geometric Mean: 3.05±1.84 ng/ml versus 2.52±1.90 ng/ml, respectively; p=0.023). Multiple logistic regression analysis indicated that higher serum levels of visfatin were significantly associated with a higher prevalence of ischemic heart disease after adjusting for potential confounders, including classical cardiovascular risk factors and circulating hs-CRP levels [odds ratio=3.26, confidence interval (1.14-9.68), p=0.027].
Conclusion: Adiponectin was not correlated with ischemic heart disease among postmenopausal women. But visfatin serum level correlated with ischemic heart disease in postmenopausal non-diabetic women independently from cardiovascular risk factors.
Subject:
Disorders of Systemic, Metabolic or Environmental Origin
Received: 2016/10/19 | Accepted: 2016/11/23 | Published: 2017/01/21
Received: 2016/10/19 | Accepted: 2016/11/23 | Published: 2017/01/21
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