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:: Volume 20, Issue 2 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(2): 163-169 Back to browse issues page
Study of Zinc Serum Level in Patients with Vitiligo, in Arak City, in 2015
Mina Mirnezami
Department of Dermatology, School of Medicine, Arak Universit of Medical Science, Arak,Iran , mirnezamim@yahoo.com
Abstract:   (3926 Views)

Background: Vitiligo is characterized by autoimmune destruction of melanocytes and it presented as a patches of depigmented on skin and mucosa. Contradictory reports have been listed from the zinc serum level in patients with vitiligo. The aim of this study was to check the zinc levels in patients with vitiligo who reffered to skin clinics of Arak University of Medical Sciences.

Materials and Methods: In this case –control study, we 103 patients vitiligo and 103 healthy people as a control group were entered to our study after obtaining knowingly testimonial.Two groups were matched according to gender and age. Zinc serum level were measured by using the spectrometery method in two groups.

Results: The mean serum level of zinc was 92.1±13.8 in patients with localized vitiligo, 81.3 ±12.7 in patients with generalized vitiligo and 91.8±16.2 in control group. Zinc level in generalized vitiligo was significantly less than the control group.

Conclusion: This study demonstrated that zinc serum level in patients with generalized vitiligo is lower than healthy people. So it can be used in treatment of these patients.

Keywords: pigmentation disorder, Zinc, Melanocyte, vitiligo
Full-Text [PDF 454 kb]   (1234 Downloads)    
Type of Study: Original | Subject: Dermatology
Received: 2016/02/6 | Accepted: 2016/08/20 | Published: 2017/04/29
1. Kanwar AJ, Kumaran MS.Childhood vitiligo: treatment paradigms. Indian J Dermatol 2012; 57(6): 466-74. [PubMed] [Google Scholar]
2. Borderé AC, Lambert J, van Geel N. Current and emerging therapy for the management of vitiligo. Clin Cosmet Investig Dermatol 2009; 12: 15-25. [PubMed] [Google Scholar]
3. Bagherani N, Yaghoobi R, Omidian M. Hypothesis: zinc can be effective in treatment of vitiligo. Indian J Dermatol 2011; 56(5): 480-4. [PubMed] [Google Scholar]
4. Whitton ME, Pinart M, Batchelor J, et al. Interventions f or vitiligo. Cochrane Database Syst Rev 2015; 24(2): CD003263. [PubMed]
5. Abreu AC, Duarte GG, Miranda JY, et al. Immunological parameters associated with vitiligo treatments: a literature review based on clinical studies. Autoimmune Dis 2015; 2015: 196537. [PubMed] [Google Scholar]
6. Patel NS, Paghdal KV, Cohen GF. Advanced treatment modalities for vitiligo. Dermatol Surg 2012; 38(3): 381-91. [PubMed] [Google Scholar]
7. Ezzedine K, Sheth V, Rodrigues M ,et al. Vitiligo is not a cosmetic disease. J Am Acad Dermatol 2015; 73(5): 883-5. [PubMed] [Google Scholar]
8. Yaghoobi R, Omidian M, Bagherani N. Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: a clinical trial. BMC Dermatol 2011; 11: 7. [PubMed] [Google Scholar]
9. Jalel A, Soumaya GS, Hamdaoui MH. Vitiligo treatment with vitamins, minerals and polyphenol supplementation. Indian J Dermatol 2009; 54(4): 357-60. [PubMed] [Google Scholar]
10. Mohammed GF, Gomaa AH, Al-Dhubaibi MS. Highlights in pathogenesis of vitiligo. World J Clin Cases 2015; 3(3): 221-30. [PubMed] [Google Scholar]
11. Cohen BE, Elbuluk N, Mu EW, et al. Alternative systemic treatments for vitiligo: a review. Am J Clin Dermatol 2015; 16(6): 463-74. [PubMed] [Google Scholar]
12. Butnaru C, Pascu M, Mircea C, et al. Serum zinc and copper levels in some dermatological disease. Rev Med Chir Soc Med Nat Lasi 2008; 112(1): 253-7. [PubMed] [Google Scholar]
13. Shameer P, Prasad PV, Kaviarasan PK. Serum zinc level in vitiligo: a case control study. Indian J Dermatol Veneol Leprol 2005; 71(3): 206-7. [PubMed] [Google Scholar]
14. Zeng Q, Yin J, Fan F, et al. Decreased copper and zinc in sera of Chinese vitiligo patients: a meta-analysis. J Dermatol 2014; 41(3): 245-51. [PubMed] [Google Scholar]
15. Brüske K, Salfeld K. Zinc and its status in some dermatologic diseases--a statistical assessment. Z Hautkr 1987; 1: 125-31. [PubMed] [Google Scholar]
16. Arora PN, Dhillon KS, Rajan SR, et al. Serum zinc level in cutaneous disorders. Med J Armed Forces India 2002; 58(4): 304-6. [PubMed] [Google Scholar]
17. Helmy MI, Gayyar EIMA, Hawas S, et al. Role of oxidative stress in the pathogenesis of vitiligo. J Pan-Arab League Dermatologist 2004; 15: 97-105. [Google Scholar]
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Mirnezami M. Study of Zinc Serum Level in Patients with Vitiligo, in Arak City, in 2015. Iran South Med J. 2017; 20 (2) :163-169
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Volume 20, Issue 2 (Iranian South Medical Journal 2017) Back to browse issues page
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