|
The Study the Effect of Vitamin D on Hypothyroidism
|
| Afsaneh Talaei *1, Fariba Ghorbani2, Parisa Naseri3, Ali Chehrea4 |
1- Endocrine and Metabolism Research Center, Arak University of Medical Science, Arak, Iran , afsanehtalaeii@yahoo.com
2- Department of Internal Medicine, School of Medicine, Arak University of Medical Science, Arak, Iran
3- Department of Statistic, School of Medicine, Arak University of Medical Science, Arak, Iran
4- Endocrine and Metabolism Research Center, Arak University of Medical Science, Arak, Iran |
|
|
Abstract: (284 Views) |
Background: Vitamin D deficiency or insufficiency is a common worldwide problem. The association between hypothyroidism and vitamin D deficiency is controversial. We aimed to study the effect of vitamin D on thyroid function in hypothyroid patients.
Material and Methods: In this case-control randomized clinical trial study, 201 hypothyroid patients reffered to endocrinology clinics in Arak, were randomly classified into two groups. All patients were taking levothyroxine. Case group received vitamin D 50000 unit weekly and control group received placebo in addition to levothyroxine. After three months, thyroid function tests were repeated and compared with the results of the beginning of the study both intra groups and inter groups by student t test and paired t test analysis.
Results: Male/Female ratio in both case and control groups were 0.24 and 0.15 respectively (P=0.1). The prevalence of vitamin D deficiency and insufficiency were 68.7 % (138) and 93.5% (188) and after vitamin D taking were 70% (34.8) and 51.2% (103) respectively.Student t test showed that TSH level in people who received vitamin D had a significant decrease in comparison to the people who received placebo (P<0.05). There were a significant change of TSH level between two groups at vitamin D level 10-30 ng/ml.
Conclusion: Most of hypothyroid patients had vitamin D deficiency and vitamin D taking improved thyroid function by TSH suppression in these patients. We recommend the screening for vitamin D deficiency in hypothyroid patients. Although, more researches are needed to clarify molecular explanations of this hypothesis.
|
|
| Keywords: Vitamin D, Hypothyroid, effect, TSH |
|
|
Full-Text [PDF 648 kb]
(111 Downloads)
|
Type of Study: Original |
Subject:
Disorders of Systemic, Metabolic or Environmental Origin
Received: 2017/07/5 | Accepted: 2017/07/5 | Published: 2017/07/5
|
|
|
|
|
|
|
| References |
1. Ross AC, Taylor CL, Yaktine AL, et al. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Washington: National Academies Press, 2011, 3-11. [ Google Scholar] 2. Agmon-Levin N, Theodor E, Segal RM, et al. Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol 2013; 45(2): 256-66. [ PubMed] [ Google Scholar] 3. Mangin M, Sinha R, Fincher K. Inflammation and vitamin D: the infection connection. Inflamm Res 2014; 63(10): 803-19. [ PubMed] [ Google Scholar] 4. Gouni-Berthold I, Krone W, Berthold HK. Vitamin D and cardiovascular disease. Curr vasc Pharmacol 2009; 7(3): 414-22. [ Google Scholar] 5. Hollick MF, Chen TC. Vitamin D deficiency a worldwide problem with health consequences. Am J Clin Nutr 2008; 87(4): 1080S-6S. [ PubMed] [ Google Scholar] 6. Choi HS, Oh HJ, Choi H, et al. Vitamin D insufficiency in Korea--a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008. J Clin Endocrinol Metab 2011; 96(3): 643-51. [ PubMed] [ Google Scholar] 7. Yasuda T, Okamoto Y, Hamada N, et al. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease. Endocrine 2012; 42 (3): 739-41. [ PubMed] [ Google Scholar] 8. Vitamin D Deficiency and Thyroid Disease. (Accessed at May 30, 2017 at https:// www.goodhormonehealth.com/VitaminD6mar10.pdf) 9. Hong Q, Xu J, Xu S, et al. Associations between serum 25-hydroxyvitamin D and disease activity, inflammatory cytokines and bone loss in patients with rheumatoid arthritis. Rheumatology (Oxford) 2014; 53(11): 1994-2001. [ PubMed] [ Google Scholar] 10. Holmøy T, Torkildsen Ø, Myhr KM, et al. Vitamin D supplementation and monitoring in multiple sclerosis: who, when and wherefore. Acta Neurol Scand Suppl 2012; (195): 63-9. [ PubMed] [ Google Scholar] 11. Joergensen C, Hovind P, Schmedes A, et al. Vitamin D levels, Microvascular complications and mortality in type 1 diabetes. Diabetes Care 2011; 34(5): 1081-5. [ PubMed] [ Google Scholar] 12. Vilarrasa N, Vendrell J, Maravall J, et al. Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population. Endocrine 2010; 38(2): 235-42. [ PubMed] [ Google Scholar] 13. Robien K, Butler LM, Wang R, et al. Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore. Br J Nutr 2013; 109(3): 493-502. [ PubMed] [ Google Scholar] 14. G R, Gupta A. vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients 2014; 6(2): 729-75. [ PubMed] [ Google Scholar] 15. Yamashita H, Noguchi S, Takatsu K, et al. High prevalence of vitamin D deficiency in Japanese female patients with Graves’ disease. Endocr J 2001; 48(1): 63-9. [ PubMed] [ Google Scholar] 16. Wang J, Lv S, Chen G, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 2015; 7(4): 2485-98. [ PubMed] [ Google Scholar] 17. Tamer G, Arik S, Tamer I, et al. Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid 2011; 21(8): 891-6. [ PubMed] [ Google Scholar] 18. Low Vitamin D Contributes to Thyroid Problems.Richards Byron. Health news 2008. (Accessed May 30, 2017, at http://www.wellnessresources.com/health/articles/low vitamin d contributes to thyroid problems) 19. Mackawy AM, Al-Ayed BM, Al-Rashidi BM. Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim) 2013; 7(3): 267-75. [ PubMed] [ Google Scholar] 20. Sar M, Stumpf WE, DeLuca HF. Thyrotropes in the pituitary are target cells for 1,25 dihydroxy vitamin D3. Cell Tissue Res 1980; 209(1): 161-6. [ PubMed] [ Google Scholar] 21. Smith MA, McHenry C, Oslapas R, et al. Altered TSH levels associated with increased serum 1, 25-dihydroxyvitamin D3: a possible link between thyroid and parathyroid disease. Surgery 1989; 106(6): 987-91. [ PubMed] [ Google Scholar] 22. Gross HA, Appleman MD, Nicoloff JT. Effect of biologically active steroids on thyroid function in man. J Clin Endocrinol Metab 1971; 33(2): 242-8. [ PubMed] [ Google Scholar] 23. Kinuta K, Tanaka H, Moriwake T, et al. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology 2000; 141(4): 1317-24. [ PubMed] [ Google Scholar] |
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
|
