Volume 20, Issue 3 (Iranian South Medical Journal 2017)                   Iran South Med J 2017, 20(3): 301-307 | Back to browse issues page

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Talaei A, Ghorbani F, Naseri P, Chehrea A. The Study the Effect of Vitamin D on Hypothyroidism. Iran South Med J 2017; 20 (3) :301-307
URL: http://ismj.bpums.ac.ir/article-1-881-en.html
The Study the Effect of Vitamin D on Hypothyroidism
Afsaneh Talaei * 1, Fariba Ghorbani2 , Parisa Naseri3 , Ali Chehrea4
1- Endocrine and Metabolism Research Center, Arak University of Medical Science, Arak, Iran , afsanehtalaeii@yahoo.com
2- Department of Internal Medicine, School of Medicine, Arak University of Medical Science, Arak, Iran
3- Department of Statistic, School of Medicine, Arak University of Medical Science, Arak, Iran
4- Endocrine and Metabolism Research Center, Arak University of Medical Science, Arak, Iran
Abstract:   (6837 Views)

Background: Vitamin D deficiency or insufficiency is a common worldwide concern. The association between hypothyroidism and vitamin D deficiency is controversial. We aimed to study the effect of vitamin D on thyroid function in hypothyroid patients.
Material and Methods: In this case-control randomized clinical trial study, 201 hypothyroid patients referred to endocrinology clinics in Arak, were randomly classified into two groups.  All patients were taking levothyroxine. Case group received vitamin D 50000 unit weekly and control group received placebo in addition to levothyroxine. After three months, thyroid function tests were repeated and compared with the results of the start of the study. Both intra-groups and inter-groups differences were analyzed by student t-test and paired t-test analysis.
Results: Male/Female ratio in case and control groups were 0.24 and 0.15 respectively (P=0.1). The prevalence of vitamin D deficiency and insufficiency was 68.7 % (138) and 93.5% (188) and after taking vitamin D was 70% (34.8) and 51.2% (103) respectively.Student t-test showed that TSH level in people who received vitamin D had a significant reduction in comparison with the placebo group(P<0.05). There was a significant difference in the change of TSH level between two groups at vitamin D level 10-30 ng/ml.
Conclusion: Most of the hypothyroid patients had vitamin D deficiency and receiving vitamin D improved thyroid function by TSH suppression in these patients. We recommend the screening for vitamin D deficiency in hypothyroid patients. However, more research is required to explain this hypothesis at the molecular level.
 
 

Keywords: Vitamin D, Hypothyroid, effect, TSH
Full-Text [PDF 645 kb]   (10194 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2016/04/19 | Accepted: 2017/01/9 | Published: 2017/07/5
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