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:: Volume 12, Issue 1 (Iranian south medical Journal 2009) ::
Iran South Med J 2009, 12(1): 40-47 Back to browse issues page
Diagnostic value of pleural fluid adenosine deaminase activity in tuberculosis pleurisy
Abbas ali Niazi Mr, Abdolsamad Sheikhzadeh Mr 1, Khalilollah Danesh Mr, Roya Alavi Naieni Mrs, Mosayeb Shahryar Mr, Behzad Narouie Mr
1- , vaheid2002005@gmail.com
Abstract:   (10744 Views)
Background: Diagnosis of tuberculosis pleurisies is difficult because of its nonspecific clinical presentation and insufficient traditional diagnostic methods. We investigated the use of adenosine deaminase (ADA) activity in tuberculosis pleurisies. Methods: A number of 85 patients were analyzed with exudative pleural effusions. Using the ROC curve, we determined the optimal cutoff for TB pleurisy. Results: A number of 58 exudative samples were nontuberculous (non-TB) and 27 were tuberculosis (TB). There was statistically significant difference (p<0.0001) between the means of pleural fluid ADA levels among the TB and non-TB populations. The prevalence of TB pleurisy in the studied population was 31%. Using the cutoff point equal to 35 for diagnosing TB effusions the sensitivity and specificity 70.3% and 91.3%, respectively. The positive predictive value (PPV) was 79.1% and the negative predictive value (NPV) was 86.8%. A pleural fluid ADA value <19 IU/L suggests that a tuberculosis effusion is highly unlikely. Conclusion: Pleural fluid total ADA assay is a sensitive and specific test suitable for rapid diagnosis of TB pleurisy.
Keywords: adenosine deaminase, tuberculosis pleurisy, diagnostic value, exudative
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Type of Study: Original | Subject: General
Received: 2008/03/18 | Accepted: 2008/08/20 | Published: 2009/09/19
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Niazi A A, Sheikhzadeh A, Danesh K, Alavi Naieni R, Shahryar M, Narouie B. Diagnostic value of pleural fluid adenosine deaminase activity in tuberculosis pleurisy. Iran South Med J. 2009; 12 (1) :40-47
URL: http://ismj.bpums.ac.ir/article-1-171-en.html

Volume 12, Issue 1 (Iranian south medical Journal 2009) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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