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Diagnostic value of pleural fluid adenosine deaminase activity in tuberculosis pleurisy
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| Abbas ali Niazi, Abdolsamad Sheikhzadeh1, Khalilollah Danesh, Roya Alavi Naieni, Mosayeb Shahryar, Behzad Narouie |
| 1- , vaheid2002005@gmail.com |
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Abstract: (11882 Views) |
| Background: Diagnosis of tuberculosis pleurisies is difficult because of its nonspecific clinical presentation and insufficient traditional diagnostic methods. We investigated the use of adenosine deaminase (ADA) activity in tuberculosis pleurisies. Methods: A number of 85 patients were analyzed with exudative pleural effusions. Using the ROC curve, we determined the optimal cutoff for TB pleurisy. Results: A number of 58 exudative samples were nontuberculous (non-TB) and 27 were tuberculosis (TB). There was statistically significant difference (p<0.0001) between the means of pleural fluid ADA levels among the TB and non-TB populations. The prevalence of TB pleurisy in the studied population was 31%. Using the cutoff point equal to 35 for diagnosing TB effusions the sensitivity and specificity 70.3% and 91.3%, respectively. The positive predictive value (PPV) was 79.1% and the negative predictive value (NPV) was 86.8%. A pleural fluid ADA value <19 IU/L suggests that a tuberculosis effusion is highly unlikely. Conclusion: Pleural fluid total ADA assay is a sensitive and specific test suitable for rapid diagnosis of TB pleurisy. |
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| Keywords: adenosine deaminase, tuberculosis pleurisy, diagnostic value, exudative |
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Full-Text [PDF 223 kb]
(1670 Downloads)
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Type of Study: Original |
Subject:
General
Received: 2008/03/18 | Accepted: 2008/08/20 | Published: 2009/09/19
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