Volume 25, Issue 1 (Iranian South Medical Journal 2022)                   Iran South Med J 2022, 25(1): 42-49 | Back to browse issues page

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Haghighatafshar M, Fatheazam R, Firuzyar T. Evaluating the Effect of Injected Dose of 99mTc- MIBI on the Quantitative Parameters of Myocardial Perfusion Imaging. Iran South Med J 2022; 25 (1) :42-49
URL: http://ismj.bpums.ac.ir/article-1-1546-en.html
1- Department of Nuclear Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
Nuclear Medicine and Molecular Imaging Research Center, Namazi Hospital, Shiraz University of Medical Sceinces, Shiraz, Iran
2- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (1020 Views)
Background: 99mTc-MIBI cardiac perfusion scanning is recognized as a clinically useful method in evaluating coronary artery disease. By the implementation of new imaging techniques and systems, it seems possible to obtain high-quality images with a lower dose of radiopharmaceuticals. The purpose of this study was to evaluate the effect of injection dose of 99mTc-MIBI on quantitative parameters of cardiac perfusion scan.
Materials and Methods: Eighty-three patients with the known probability of coronary artery disease were imaged three times (15, 120, and 180 min) after one injection during the stress phase. Assuming that 99mTc-MIBI has not any significant redistribution at this time, the only parameter which has been changed is the amount of accumulated radioactivity within the myocardium. In this way, we have three different images with different deposited doses in the myocardium from each patient. Then quantitative data of End Systolic Volume (ESV), End Diastolic Volume (EDV), and Ejection Fraction (EF) were calculated and compared.
Results: Examination of quantitative scanning data indicates that the changes in EF data were non-significant and that the changes in ESV and EDV were significant over time.
Conclusion: In this study, assuming a dose reduction of radioactivity up to 50% of the initial dose based on cumulative dose in myocardial and imaging time, no clinically significant changes in quantitative cardiac perfusion scan variables such as ESV, EDV and EF occurred.
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Type of Study: Original | Subject: Radiology. Diagnostic Imaging
Received: 2020/01/26 | Accepted: 2022/02/19 | Published: 2022/03/13

1. Berrington de Gonzalez A, Kim KP, Smith-Bindman R, et al. Myocardial Perfusion Scans: Projected Population Cancer Risks From Current Levels Of Use In The United States. Circulation 2010; 122(23): 2403-10.
2. Santana CA, Garcia EV, Faber TL, et al. Diagnostic Performance Of Fusion Of Myocardial Perfusion Imaging (MPI) And Computed Tomography Coronary Angiography. J Nucl Cardiol 2009; 16(2): 201-11.
3. Assadi M, Nabipour I, Saghari M, et al. The Role Of Myocardial Perfusion Imaging In The Screening Of Silent Ischemia In Diabetic Patients. Iran South Med J 2010; 13(1): 59-71. (Persian)
4. Fallahi B, Haghighatafshar M, Farhoudi F, et al. Comparative Evaluation Of The Diagnostic Accuracy Of 99mtc-Sestamibi Gated SPECT Using Five Different Sets Of Image Acquisitions At Stress And Rest Phases For The Diagnosis Of Coronary Artery Disease. Am J Nucl Med Mol Imaging 2014; 4(1): 10-6.
5. Loong C, Anagnostopoulos C. Diagnosis Of Coronary Artery Disease By Radionuclide Myocardial Perfusion Imaging. Heart 2004; 90(suppl 5): v2-v9.
6. Stabin MG. Radiopharmaceuticals For Nuclear Cardiology: Radiation Dosimetry, Uncertainties, And Risk. J Nucl Med 2008; 49(9): 1555-63.
7. Eisenberg MJ, Afilalo J, Lawler PR, et al. Cancer Risk Related To Low-Dose Ionizing Radiation From Cardiac Imaging In Patients After Acute Myocardial Infarction. CMAJ 2011; 183(4): 430-6.
8. Ozasa K, Shimizu Y, Suyama A, et al. Studies Of The Mortality Of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview Of Cancer And Noncancer Diseases. Radiat Res 2011; 177(3): 229-43.
9. Pierce DA, Preston DL. Radiation-Related Cancer Risks At Low Doses Among Atomic Bomb Survivors. Radiat Res 2000; 154(2): 178-86.
10. Brenner DJ, Hall EJ. Computed Tomography—An Increasing Source Of Radiation Exposure. N Engl J Med 2007; 357(22): 2277-84.
11. Garcia EV, Faber TL, Esteves FP. Cardiac Dedicated Ultrafast SPECT Cameras: New Designs And Clinical Implications. J Nucl Med 2011; 52(2): 210-7.
12. Duvall WL, Sweeny JM, Croft LB, et al. Reduced Stress Dose With Rapid Acquisition CZT SPECT MPI In A Non-Obese Clinical Population: Comparison To Coronary Angiography. J Nucl Cardiol 2012; 19(1): 19-27.
13. Timmins R, Klein R, Petryk J, et al. Reduced Dose Measurement Of Absolute Myocardial Blood Flow Using Dynamic SPECT Imaging In A Porcine Model. Med Phys 2015; 42(9): 5075-83.
14. Lyon MC, Foster C, Ding X, et al. Dose Reduction In Half-Time Myocardial Perfusion SPECT-CT With Multifocal Collimation. J Nucl Cardiol 2016; 23(4): 657-67.
15. Jin M, Niu X, Qi W, et al. 4D Reconstruction For Low‐Dose Cardiac Gated SPECT. Med Phys 2013; 40(2): 022501.

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